Genetic and epigenetic patterns in patients with the head-and-neck paragangliomas associate with differential clinical characteristics

ConclusionsOur results suggested that epigenetic inactivation on multiple TSGs may serve as a key mechanism for the progressive behaviors of SDH-mutated HNPGLs. Thus, an interplay between genetic status, epigenetic alterations, and clinical features might be established in the disease.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research