Structural Exploration of Synthetic Chromones as Selective MAO-B Inhibitors: A Mini Review.

Structural Exploration of Synthetic Chromones as Selective MAO-B Inhibitors: A Mini Review. Comb Chem High Throughput Screen. 2017 Feb 27;: Authors: Mathew B, Mathew GE, Petzer JP, Petzer A Abstract Specific inhibitors of monoamine oxidase (MAO)-B are considered useful therapeutic agents in targeting of neurological disorders like Alzheimer's and Parkinson's diseases. Due to the academic challenge of designing new hMAO-B inhibitors and the possibility of discovering compounds with improved properties compared to existing MAO-B inhibitors, a number of research groups are searching for new classes of chemical compounds that may act as selective hMAO-B inhibitors. Among these, chromone (4H-1-benzopyran-4-one) derivatives have recently emerged as a chemotype with specific and high potency MAO-B inhibition. Chromones are structurally related to series of coumarins and chalcones, which are well-known inhibitors of MAO-B. The experimental evidence has demonstrated that most of the chromone skeleton derived compounds shown potent, reversible and selective type of hMAO-B inhibitors. The current review focuses on the MAO-B inhibitory properties of various synthetically derived chromones with specific emphasis on the structure-activity relationships and molecular recognition of MAO-B inhibition by this class. This review cover the recent updates present in the literature and will certainly provide a greater insight for the design and developmen...
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research