Cilostazol: An Option for Ischemic Stroke After ICH? Cilostazol: An Option for Ischemic Stroke After ICH?

The antiplatelet agent cilostazol showed promising results among this difficult-to-treat group in the PICASSO trial.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

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CONCLUSION: BPPV is the most frequent diagnosis seen in the ED; however, physicians need to document nystagmus more precisely and perform diagnostic tests systematically, in order to make an accurate diagnosis. To avoid misdiagnoses, ED physicians and ENT specialists should be able to recognize central signs in patients with an acute vestibular syndrome. Every fourth patient does not receive a definitive diagnosis. Diagnostic ED workup for patients with dizziness needs further improvement. PMID: 32221628 [PubMed - as supplied by publisher]
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
ConclusionsMore macrovascular and microvascular complications were found in Northern compared to Southern patients, and the largest difference also appeared in the younger age groups under 55, which may be meaningful to a screening and treatment strategy according to geographic differences.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This randomized clinical trial examines whether in-hospital treatment with remote ischemic perconditioning that is administered within 6 hours of symptom onset, with or without reperfusion therapy, can reduce brain infarction volume growth in patients with acute ischemic stroke.
Source: JAMA Neurology - Category: Neurology Source Type: research
AbstractCaseous Mitral Annular Calcification (CMAC) is seen in 0.6% of Mitral annular Calcification (MAC) and carries an increased risk for ischemic stroke. The typical location is Posterior Mitral Annular area and arises as degeneration of MAC. Typical Echocardiographic features along with Cardiac MRI and CT imaging features are diagnostic.
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
We report a 42-year old men who presented to our observation with acute tongue swelling and atrophy of left side of tongue from a hypoglossal nerve injury. A magnetic resonance imaging revealed a denervation of the left half of the tongue from a hypoglossal nerve injury due to left extracranial internal carotid artery (ICA) dissection, without evidence of ischemic stroke. The urine toxicology screen test revealed a positivity for cocaine. This case report suggest to perform in young patient a toxicological drug screening test in presence of ICA dissection with hypoglossal nerve injury and an acute tongue swelling. However ...
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research
This study aimed to define the effects of LSZ on proinflammatory mediators and neuroprotective effects on middle cerebral artery occlusion and refusion (MCAO/R) rats. Rats were treated with different doses of LSZ (0.54, 1.62, and 4.32 g/(kg·d)) in a week after model building. LSZ could improve the survival rate, ischemic stroke outcome, and infarct volume. In addition, significant decrease was observed in reactive oxygen species (ROS) levels and inflammatory factor levels in LSZ-treated groups, concomitant with increase in activities of superoxide dismutase (SOD), neurosynaptic remodeling, and decrease in bra...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI[1] major bleeding. VOYAGER PAD is the only study to show a significant benefit...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
Moyamoya disease is a cerebrovascular disease of unknown origin causing progressive stenosis of the intracranial arteries in the circle of Willis.1,2 Stenoocclusive lesions and the subsequent hemodynamic compromise result in the formation of dilated, fragile collateral vessels at the base of the brain, which are termed moyamoya vessels. The presentation of patients with these lesions varies from asymptomatic to symptoms of headache, epilepsy, and ischemic and hemorrhagic stroke. Patients with moyamoya disease sometimes have concomitant extracranial arterial stenosis3; of all the extracranial arteries reported, the most com...
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Case Report Source Type: research
Publication date: Available online 27 March 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Javad Alizargar, Nan-Chen Hsieh, Shu-Fang Vivienne Wu
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
This study suggests plasma exosome with melatonin pretreatment might be a more effective strategy for patients with ischemic brain injury. Further exploration of ke y molecules in plasma exosome may devote more therapeutic value for cerebral ischemic injury.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Rattus norvegicus Source Type: research
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