Cydar lands Roche exec for 3D imaging software play

Cydar EV, a medical software start-up, said this week that it hired several new directors, including Roche’s recently-retired chairman Franz Humer. The U.K.-based company is developing cloud-based software to produce 3D images of a patient’s blood vessels in X-ray guided endovascular surgery. Cydar said Humer will bring a “wealth of commercialization” and key developmental insights for future applications of its software. At Roche, Humer was a driving force behind the Swiss drugmaker’s 2009 takeover of Genentech. Since the acquisition, the U.S. biotech has produced some of Roche’s best-selling cancer therapies. Humer also previously worked at GlaxoSmithKline (NYSE:GSK) and Merck (NYSE:MRK). Alongside Humer, Cydar hired Mervyn Davies and James Downing as non-executive directors and John Deanfield to head a new scientific and technology advisory board. Cydar won regulatory clearance for its software in the U.S. last year and its tool is in use at several UK hospitals, according to the company. The guidance system features fully-automatic computer vision, which is used to track patients during X-ray guided surgery. The company said that its technology combines diagnostic scanning, planning information and real-time imaging. The software is designed to be compatible with any X-ray system and to provide the operating surgeon with a detailed, 3D augmented reality view of the patient’s anatomy. Early clinical studies indicated...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Imaging Software / IT Surgical Wall Street Beat Cydar EV Genentech GlaxoSmithKline plc Merck Roche Source Type: news

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Source: Headlines - Category: Radiology Source Type: news
CONCLUSIONS:Our findings suggest that LMWH might represent an effective and safe strategy for the management of CVT in cancer patients. The findings are consistent with results from large randomized trials for outcomes of cancer associated venous thrombosis in other anatomical locations. The impact of thrombus recanalization in recurrent thrombosis and bleeding outcomes deserves further exploration. Limitations to our study are the retrospective and non-randomized design for the adjudication of treatment agents.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 332. Antithrombotic Therapy Source Type: research
Authors: M R, S V, Ramirez JT, A V, L L Abstract Novel materials are explored very often by material scientists to design an efficient drug delivery system to target carcinoma cells. Among various nanosystem, functionalized Iron oxide Nanoparticles (IoNP) were definitely studied especially to target, endocyte and release drug moieties inside the cells. This IoNP platform is usually composed of an inorganic core and a highly biocompatible shell layer in order to perform numerous tasks at the same time, such as drug delivery, multimodal imaging, and instantaneous monitoring, along with collective therapeutic approach...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
In this study, the chemically crosslinked hydrogels of carboxymethyl chitosan and polyvinyl alcohol were fabricated by the free radical polymerization. Successful polymerization was confirmed by Fourier transform infrared spectroscopy, while x-ray diffraction, thermogravimetric analysis, and differential scanning calorimetric measurements helped in investigating crystallinity and thermal behavior of the products. Morphological characterization was performed by scanning electron microscopy. The increased incorporation of carboxymethyl chitosan and polyvinyl alcohol enhanced the swelling, drug loading, and in-vitro drug rele...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
ConclusionsThe present study describes the development of an image analytic module for assessing tumor growth rate and the data demonstrates the functionality and reproducibility of the module in a pilot cohort of EGFR-mutant NSCLC patients treated with EGFR-TKI. The image analytic module is an initial step for clinical translation of the tumor growth rate approach to guide cancer treatment in precision oncology.
Source: European Journal of Radiology - Category: Radiology Source Type: research
PEGylated Poly(α-lipoic acid) Loaded with Doxorubicin as a pH and Reduction Dual Responsive Nanomedicine for Breast Cancer Therapy. Biomacromolecules. 2018 Oct 22;: Authors: Yang H, Shen W, Liu W, Chen L, Zhang P, Xiao C, Chen X Abstract Disulfide-containing nanoparticles are promising vehicles for anticancer drug delivery. However, the preparation of disulfide-containing nanoparticles usually relies on complex synthetic procedures. In the present work, a PEGylated poly(α-lipoic acid) (mPEG-PαLA) copolymer was facilely synthesized and used for pH and reduction dual responsive drug de...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research
In this report, we propose that the molecular mechanisms of beneficial actions of CR should be classified and discussed according to whether they operate under rich or insufficient energy resource conditions. Future studies of the molecular mechanisms of the beneficial actions of CR should also consider the extent to which the signals/factors involved contribute to the anti-oxidative, anti-inflammatory, anti-tumor and other CR actions in each tissue or organ, and thereby lead to anti-aging and prolongevity. RNA Interference of ATP Synthase Subunits Slows Aging in Nematodes
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, the synthesized DOX@nanocomposite can be applied in theranostic applications and anticancer drug delivery owing to admissible properties. PMID: 30307331 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
bin Yin Jian Ni Sustained-release preparation is a hot spot in antitumor drug research, where the first task is to select suitable drug carriers. Research has revealed that carboxylic acid iron metal–organic frameworks (MOFs), constructed from iron (Fe) ions and terephthalic acid, are nontoxic and biocompatible. Due to the breathing effect, the skeleton of this mesoporous material is flexible and can reversibly adapt its pore size through drug adsorption. Therefore, we chose one kind of Fe-MOF, MIL-53(Fe), as a carrier for the anticancer drug oridonin (Ori). In this work, we report the design and synthesis ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Lijun You, Xiaocui Liu, Zhexiang Fang, Qianhui Xu, Qiqing ZhangAbstractA new folic acid (FA)-conjugated poly (lactic-co-glycolicacid) (PLGA)-polyethylene glycol (PEG) nano-noisome was prepared. The noisome was employed as a drug delivery system to load curcumin (Cur) as a model drug and fluorescent probe for cervical cancer therapy and cell imaging. The Fe3O4@PLGA-PEG@FA noisomes were prepared through facile emulsion solvent evaporation and conjugation chemistry method, possessing the properties of high rapid magnetic separati...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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