Cydar lands Roche exec for 3D imaging software play

Cydar EV, a medical software start-up, said this week that it hired several new directors, including Roche’s recently-retired chairman Franz Humer. The U.K.-based company is developing cloud-based software to produce 3D images of a patient’s blood vessels in X-ray guided endovascular surgery. Cydar said Humer will bring a “wealth of commercialization” and key developmental insights for future applications of its software. At Roche, Humer was a driving force behind the Swiss drugmaker’s 2009 takeover of Genentech. Since the acquisition, the U.S. biotech has produced some of Roche’s best-selling cancer therapies. Humer also previously worked at GlaxoSmithKline (NYSE:GSK) and Merck (NYSE:MRK). Alongside Humer, Cydar hired Mervyn Davies and James Downing as non-executive directors and John Deanfield to head a new scientific and technology advisory board. Cydar won regulatory clearance for its software in the U.S. last year and its tool is in use at several UK hospitals, according to the company. The guidance system features fully-automatic computer vision, which is used to track patients during X-ray guided surgery. The company said that its technology combines diagnostic scanning, planning information and real-time imaging. The software is designed to be compatible with any X-ray system and to provide the operating surgeon with a detailed, 3D augmented reality view of the patient’s anatomy. Early clinical studies indicated...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Imaging Software / IT Surgical Wall Street Beat Cydar EV Genentech GlaxoSmithKline plc Merck Roche Source Type: news

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Elekta (STO:EKTA B) said today it won CE Mark approval in the European Union for its Elekta Unity magnetic resonance radiation therapy system. The Stockholm-based company touted that its Unity system allows clinicians to deliver radiation doses while simultaneously visualizing the tumor and surrounding tissue through MR imaging. The system also features integrated advanced tools that allow the operator to adapt treatment based on anatomical information. “Unity is a tremendous innovation in patient care, one that enables a scan-plan-treat approach to developing tailored regimens that should yield substantive clinical ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Imaging Oncology Regulatory/Compliance Elekta Source Type: news
Abstract The current experiment reveals the anticancer properties of silver nanoparticles (AgNPs) synthesized using aqueous leaf extract of Cichorium intybus, a significant medicinal plant. The characteristics of AgNPs were continuously studied by powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), zeta potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) analysis. Current microscopic results show that produced AgNPs were spherical in shape with an average size of 17.17 nm. A strong peak between 2 and 4 ...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, we anticipate that these types of Ln(III) complexes have potential and could be further explored for applications as antitumor agents. Graphical abstract
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Conclusion: The 18F-Ala-BF3 was successfully synthesized through one-step 18F-19F isotope exchange with fine specific activity and good radiochemical yield. Following in vitro bio-distribution and in vivo PET imaging in gastric tumor xenografts bearing mice and healthy mice revealed high tumor to normal tissue rate consist with fine tumor imaging of 18F-Ala-BF3. This study shed light on ASCT2 as a cancer biomarker for clinical diagnosis, and emphasized the usefulness of BAAs in tumor PET imaging. 18F-Ala-BF3 represents a useful molecular platform for tumor diagnosis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research
Conclusions: Early favorable signs of FDG-PET parameters may vary among diseases with immune checkpoint inhibitors. Mean FDG uptake was elevated in several immune-related organs at the early restaging scan. Among them, elevated FDG accumulation in thyroid might be a candidate sign of monitoring effectiveness of immunotherapy observed earlier than immune-related lymphadenopathy. Relationship between % change () of PET parameters and patients outcome% chage (Î") of PET parametersMalignant melanoma(Odds, 95%CI, p)Malignant lymphoma (Odds, 95%CI, p)Renal cell carcinoma (Odds, 95%CI, p)Î&quo...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Other Solid Tumors Source Type: research
Conclusion Imaging will likely play a central role in understanding immune cell trafficking to tumors, evaluating sites of potential toxicity, and determining the efficacy of cell-based therapies. We show in vivo BLI and PET/CT monitoring of CAR T cells trafficking to solid tumors. This triple reporter imaging approach allows facile monitoring of cells in preclinical studies (via fluorescence and/or BLI), and we anticipate that the [18F]FPTMP/dhfr PET probe and reporter gene pair will be useful for tracking CAR T cells in the clinical setting. Future studies will test whether trafficking of CAR T cells correlates with therapeutic response.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Center for Therapy Excellence YIA Symposium Source Type: research
Conclusion: D-TiO2 NPs as UV photosensitizer for CR induced PDT were prepared, and exhibited high cellular uptake and low cytotoxicity to 4T1 cells. Ga-68 demonstrated significantly better tumor suppression than F-18 against 4T1 cancer cells both in vitro and in vivo, suggesting that Gallium-68 was very attractive for depth-independent cancer therapy without using any external light source.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science Posters (Oncology) Source Type: research
Conclusions In this study, we have developed NK cell-based theranostic platforms using radiolabeled and gold coated iron oxide nanoparticles, and demonstrated that PET/MRI/PA multimodal imaging and synergistic therapy by adoptive immunotherapy and NIR light-induced phototherapy therapy. This multimodal theranosis based on NK cells paves the way for the rational design of immuno-plasmonic theranostic platform. References 1. Zhigang Tian et al., "NK cell-based immunotherapy for malignant diseases", Cellular &Molecular Immunology, 2013, 10, 230-252. 2. Heike E. Daldrup-Link et al., "Monitoring of Natural Ki...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Novel Multimodality and Nonradioactive Probes Source Type: research
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Yalei Miao, Yudian Qiu, Wenjing Yang, Yuqi Guo, Hongwei Hou, Zhongyi Liu, Xubo Zhao Dual pH-/reduction-sensitive biodegradable poly(methacrylic acid-co-N,N-bis(acryloyl)cystamine)/chitosan/dimethylmaleic anhydride-modified chitosan (PMAABACy/CS/CS-DMMA) nanoparticles with PMAABACy cores as carriers and dimethylmaleic anhydride-modified chitosan as charge reversible shells were rationally designed. PMAABACy cores using N,N-Bis(acryloyl)cystamine (BACy) as a crosslinker and methacrylic acid (MAA) as a monomer were fabrica...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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