CXCR4 (CD184) Expression on Stem cell Harvest and CD34+ Cells Post-transplant
Conclusion SDF-1/CXCR4 axis plays a crucial role in engraftment; however, more studies are warranted to assess their expression post-transplant. Evaluating the ligand (chemokine, SDF-1) or its receptor (CXCR4) may serve as potential surrogate markers for assessment of engraftment.
Aneurysms of the renal arteries are rare, probably under-diagnosed, with an incidence estimated at 0.01%. A size exceeding 20mm and the presence of symptoms such as hypertension represent a therapeutic indication for most authors. Endovascular techniques are used more and more to treat proximal lesions and auto-transplantation is the technique of reference for intra-parenchymatous lesions. However, most hilar, non-intra-parenchymatous lesions can be treated in situ without cooling and with a reasonable clamping time.
The objective of this work was to study the mid-term results of the angioplast y of the renal artery on transplanted kidneys.
To evaluate the long-term results of the treatment of popliteal aneurysms by transposition of superficial femoral autografts.
The objective of this work was to evaluate the long-term results in patients treated with venous allograft bypass for infra-inguinal arterial revascularization.
The objective of this preliminary study was to evaluate the clinical results at one year of arterial grafts harvested in the mortuary after the death of the donor.
Aortic infections have a high perioperative rate of morbi-mortality. The treatment consists in the eradication of the infected site in association with a hemodynamically and microbiologically perennial revascularization with a substitute having the best resistance possible to infection. For this purpose we evaluated arterial allografts to treat infections of the native and prosthetic abdominal aorta.
Our objective was to evaluate the long-term results of the treatment of secondary aorto-enteric fistulae by in situ reconstruction with arterial allografts. The principal criterion of judgment was short- (30-day), mid- (12 months) and long-term (36 months) survival. The secondary criteria of judgment were primary patency, the rate of reinfection and the postoperative morbidity.
Abstract: Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Immunohistochemical staining with anti-c-CBL antibody was performed on lesional biopsies from a total of 65 patients with atopic dermatitis, allergic contact der...
We describe a 61-year-old African American diabetic gentleman who presented with nodules in a linear distribution on the flank. Histopathologic examination of a biopsied nodule revealed a pandermal sheet-like infiltrate of plasma cells and histiocytes, some demonstrating elastophagocytosis and emperipolesis. The lesional histiocytes were S100 and CD68 positive and CD1a negative—findings consistent with a diagnosis of CRDD. Additional laboratory work-up performed 12 weeks after the biopsy was taken revealed an elevated serum κ light chain concentration of 37.26 mg/L (reference range: 3.30–19.40 mg/L), whic...
Abstract: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) represents approximately 20% of cutaneous B lymphomas with an intermediate prognosis. Spontaneous regression is uncommon; there are only 2 published cases. An 83-year-old woman presented 2 orange erythematous nodules on the back of her right leg with an elastic consistency, infiltrated, painful to the touch, and of an 8-month evolution. A histological examination revealed a dense cellular dermo-hypodermic infiltrate sparing the papillary dermis, composed of large cells with immunoblast and centroblast morphology and frequent mitosis. Immunohis...
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