Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium
Nature Reviews Urology 14, 139 (2017). doi:10.1038/nrurol.2016.268 Authors: Magnus Unemo &Jorgen S. Jensen The emergence of antimicrobial resistance (AMR) is a major concern worldwide and already compromises treatment effectiveness and control of several bacterial sexually transmitted infections (STIs). Neisseria gonorrhoeae and Mycoplasma genitalium are evolving into so-called superbugs that can become resistant, both in vitro
Surgical site infections (SSI) represent undesired and potentially fatal complications in the context of colorectal surgery. On the other hand, antimicrobial resistance (AMR) is known for increasing the risk of adverse outcomes in several clinical conditions. We aimed to evaluate the association between AMR diagnosis and postoperative outcomes in patients that underwent open colectomy and developed a SSI.
Conditions: Antimicrobial Resistance; Neonatal Sepsis Intervention: Other: No intervention Sponsors: Children's Hospital of Fudan University; Chinese Neonatal Network Not yet recruiting
Conclusions The relatively high IR and low CR of penile HPV-16 and HPV-18 among HIV-negative MSM correlates with their high prevalence and oncogenic potential. Incident HPV infections were associated with recent sexual risk behavior.
Conclusions While public health efforts often focus on MSM, non-MSM with STIs is also a subgroup at high risk of incident HIV diagnosis. Non-MSM and MSM with any STI, particularly syphilis, should be prioritized for HIV testing and prevention interventions.
Conclusions Patients with undetermined risk for HIV constituted a large proportion of clinic visits and had a large volume of sexual health needs but rarely received PrEP when indicated. To end the HIV epidemic in the United States, prevention efforts must include people who fall outside traditional risk categories.
Conclusions Integrating STI testing into routine HIV care was feasible, self-collecting specimens was highly acceptable, but uptake of testing was low. Where blanket screening to the entire clinic population may not be feasible because of resource limitation, one strategy could be to prioritize sexually active patients, younger patients, and women.
Conclusion: Alarming increase in the resistance to commonly used antimicrobials for gonorrhoea in our study, especially of fluoroquinolones, is a clarion call for the urgent need for prudence in prescribing them. Observing the rampant resistance exhibited by N. gonorrhoeae, it is clear that the day is not far when it will acquire a superbug status and become intractable to treatment by the available antibiotics.
Conclusion This large study found an association between having the MeNZB vaccine and a reduced likelihood of being diagnosed with gonorrhoea. But it's difficult to form any firm conclusions because of the nature of the case and control groups. For example, given that both groups were sexually active, we don't know why the majority of people with gonorrhoea didn't also have a chlamydia infection, and how this may have affected the results. It could just be down to pure chance and have nothing to do with the vaccine. So before we celebrate the alleged "cure of gonorrhoea", there are many things to consider: T...
Conclusion The increase in antimicrobial resistance towards drugs used to treat gonorrhoea is reaching a critical stage, especially given how common the infection is worldwide, with an estimated 78 million new cases in 2012. This study raises concerns around an important topic while also proposing strategies to help address the slow pace of research and development of new drugs. The prevention of gonorrhoea is equally, if not more, important. The most effective way to prevent gonorrhoea is to always use a condom during sex, including anal and oral sex. Read more advice about sexually transmitted infections and how to prev...
7 July 2017 – Data from 77 countries show that antibiotic resistance is making gonorrhoea – a common sexually-transmitted infection – more difficult, and sometimes impossible, to treat. Some countries – particularly high-income ones, where surveillance is best – are finding cases of the infection tha t are untreatable by all known antibiotics. These cases may just be the tip of the iceberg, as gonorrhoea is more common in lower-income countries.