110: seasonality in human cases of crimean-congo hemorrhagic fever and its dependence on temperature - empirical evidence from pakistan

In this study, we carried out time series analysis of data (2007–2010) from three tertiary care hospitals to provide empirical evidence of seasonality in disease occurrence and its association with temperature. Cosinor model revealed statistically significant seasonality in monthly number of CCHF patients admitted to the hospitals. The estimated amplitude was 3.24 cases per month with phase (i.e. peak location) in mid-June and low point (i.e. nadir) in mid-December. Generalized linear model revealed association between monthly number of CCHF admissions and average monthly temperature. A unit increase in temperature increased expected number of patients by 1.10 (95% CI : 1.07–1.13). A strong positive correlation (r=0.98) between between fitted values of GLM and cosinor models indicate relation between seasonal pattren and temperature. The risk should be managed according to seasonality and temperatue can be used as predictor in disease modeling.
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access Poster Source Type: research

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Conclusion:Early  detection plays an important role in patients ’ outcome. Considering that the most cases of the disease are associated with some contacts around Eid ‑Adha and death attributable to CCHF usually occurin the first 7 days of disease onset, educating population, and especially slaughters, gloves using  by housewives during contacts with meat or animal products, and early detection and immediate  treatment would have essential roles in primary and secondary prevention of CCHF. Hemorrhagicmanifestations and low platelet count provide a clue to early detection of disease. Vaginal blee...
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Authors: Shahbazi N, Firouz SK, Karimi M, Mostafavi E Abstract Crimean-Congo haemorrhagic fever (CCHF) is a zoonotic viral haemorrhagic disease. This disease is more common in people who work with animals infected with CCHF virus. The aim of this study was to evaluate the CCHF exposure in high-risk occupational groups in Kurdistan Province in the west of Iran. This cross-sectional study was conducted in 2014 in three counties of Kurdistan Province, viz. Sanandaj, Marivan and Sarvabad. About 50 butchers and slaughterhouse workers, 50 hunters, 50 health care workers and 100 subjects referred to clinical laboratories ...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Golden Crimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe. CCHFV is also an emerging virus, with recent outbreaks in Western Europe. CCHFV can infect a large number of wild and domesticated mammalian species and some avian species, however the virus does not cause severe disease in these animals, but can produce viremia. In humans, CCHFV infection can lead to a severe, life-threating disease characterized by hemodynamic instability, hepatic injury and neurological disorders, with a worldwide lethality rate of ~20–30%. The pathogen...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
In conclusion, climate appeared to affect the number of CCHF patients. We believe that the number of patients presenting to the hospital with CCHF could be predicted by taking into account climatic properties of the places where CCHF has been recorded, along with undertaking necessary measures. PMID: 31168176 [PubMed - in process]
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Publication date: Available online 28 May 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Huseyin Kayadibi, Derya Yapar, Ozlem Akdogan, Nuriye N. Ulusu, Nurcan BaykamAbstractCrimean-Congo hemorrhagic fever (CCHF) is fatal. Therefore, it is very important to use an inexpensive, easily accessible, quick and accurate screening index based on clinical signs and laboratory parameters to identify patients suspected of having CCHF.Laboratory test results on the day of hospitalization for 268 inpatients suspected of having CCHF were used to calculate the laboratory section of the Hitit Index, while 65 of these were also monito...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Authors: Papa A Abstract INTRODUCTION: Crimean-Congo hemorrhagic fever (CCHF) is a potentially severe tick-borne viral disease endemic in several regions of Europe, Africa and Asia. Rapid and reliable diagnosis is essential for early initiation of patient's treatment and for prompt implementation of appropriate precaution and infection control measures to prevent further spread of the disease. Areas covered: A literature search was undertaken on available approaches for laboratory diagnosis of CCHF infections and the advantages and limitations of the assays are discussed. Expert opinion: Given that the genetic vari...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
Background: Crimean-Congo hemorrhagic fever (CCHF) is an endemic zoonosis in Kastamonu, Turkey. Clinical and laborato- ry findings may not be specific in the early phase of the disease, hence bringing a challenge to the clinician. Objective: We aimed to distinguish CCHF cases among all suspected cases by comparing them with non-CCHF cases with respect to characteristics during admission.Methods: Cases with a presumptive diagnosis of CCHF at a secondary care hospital in Kastamonu in between 2014-2017 were evaluated, retrospectively. CCHF and non-CCHF cases were compared with respect to their clinical, laboratory and epidemi...
Source: African Health Sciences - Category: African Health Source Type: research
Abstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that can evolve into deadly hemorrhagic fever and that is endemic in many parts of Europe, Middle East, Central Asia, and Africa. Because of several reports about CCHF outbreaks in the south of Sudan during the last years, we examined in this study if unrecognized CCHF-V infections also occurred in the eastern and central parts of the country. The study examined the seroprevalence of CCHF virus infection in 464 sera from three regions of Sudan without previous reports of CCHF infection. The total CCHF virus seroprevalence was 2.6% (12 sera). T...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne Nairovirus that causes severe hemorrhagic fever with a mortality rate of up to 30% in certain outbreaks worldwide. The virus has wide endemic distribution. There is no effective antiviral therapeutic or FDA approved vaccine for this zoonotic viral illness. The multifunctional CCHFV nucleocapsid protein (N protein) plays a crucial role in the establishment of viral infection and is an important structural component of the virion. Here we show that CCHFV N protein has a distant RNA-binding site in the stalk domain that specifically recognizes the vRNA panhandle, f...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
Conclusions: Especially during summers when the disease is seen frequently, the history of tick contact should be questioned and tick should be searched in the examination in the patients with suspected clinical findings. A significant number of the patients do not have a known tick contact. Therefore, training meetings should be organized about the symptoms and findings of the disease in the endemic areas and awareness should be raised among the community and the doctors working in emergency services and primary care. PMID: 30938129 [PubMed - in process]
Source: Turkish Society for Parasitology - Category: Parasitology Authors: Tags: Turkiye Parazitol Derg Source Type: research
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