110: seasonality in human cases of crimean-congo hemorrhagic fever and its dependence on temperature - empirical evidence from pakistan
In this study, we carried out time series analysis of data (2007–2010) from three tertiary care hospitals to provide empirical evidence of seasonality in disease occurrence and its association with temperature. Cosinor model revealed statistically significant seasonality in monthly number of CCHF patients admitted to the hospitals. The estimated amplitude was 3.24 cases per month with phase (i.e. peak location) in mid-June and low point (i.e. nadir) in mid-December. Generalized linear model revealed association between monthly number of CCHF admissions and average monthly temperature. A unit increase in temperature increased expected number of patients by 1.10 (95% CI : 1.07–1.13). A strong positive correlation (r=0.98) between between fitted values of GLM and cosinor models indicate relation between seasonal pattren and temperature. The risk should be managed according to seasonality and temperatue can be used as predictor in disease modeling.
This study was conducted to confirm the etiology of suspected hemorrhagic fever cases in order to support their clinical management. The genotype classification of CCHFV strains was determined to explore their phylogenetic relationship with strains in the region.
Background: Crimean-Congo Haemorrhagic Fever (CCHF) is a viral haemorrhagic fever characterized by a febrile illness and haemorrhagic manifestations that develop in late-stage disease. The mortality ranges from 4% to 30% with higher case fatality rates (CFR) in nosocomial settings. CCHF is endemic in Pakistan where it was found in 1976, with continuing sporadic cases and high mortality in nosocomial settings. The whole burden of the disease in Pakistan is not fully known. We aimed to systematically review the incidence and mortality of CCHF in Pakistan from 1960 to 2019.
CONCLUSION: As it takes a considerable time for a definitive diagnosis, determining epidemiological features and risk factors is an important step for preliminary diagnosis of CCHF as well as early implementation of precautions against nosocomial transmission of the virus. PMID: 32749537 [PubMed - as supplied by publisher]
This study presents quantitative CCHFV load data in ruminant species at slaughter and interprets the likelihood of transmission for employees working in slaughterhouses in CCHFV-endemic regions.
by Massab Umair, Adnan Khurshid, Muhammad Masroor Alam, Ribqa Akhtar, Muhammad Salman, Aamer Ikram Being an endemic country for Crimean Congo hemorrhagic fever (CCHF), this study aimed to explore the genetic diversity of CCHF virus (CCHFV) detected in Pakistan during 2019. Serum samples from patients with clinical signs of hemorrhagic fever attending tertiary care hospitals in Pakistan were tes ted for CCHFV RNA using real-time PCR at Department of Virology, National Institute of Health. The partial S-gene fragments were directly sequenced to determine the prevailing CCHFV genotypes and their molecular epidemiology in Pak...
Crimean-Congo hemorrhagic fever is the most geographically widespread tick-borne virus, with infection resulting in mortality in up to 30% of cases. Clinical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory diagnostics should be utilized for patients with residence in or travel to regions of endemicity in whom the disease is suspected. This minireview provides an overview of laboratory tests available for Crimean-Congo hemorrhagic fever (CCHF) and their utility in diagnosis with a focus on diagnosing CCHF in humans.
ConclusionsThe highest seroprevalence of CCHF is found in central and eastern European countries. Southern and western Europe countries, such as Greece and Spain, have low levels of endemicity, but the spread of the infection, which is associated with climate change, is a possibility that we should keep in mind. Further studies, especially larger seroprevalence studies in humans and animals, are needed to establish the current status of the CCHF epidemiology and to generate standardized guidelines for action in the region.
Abstract We conducted a cross-sectional survey of Crimean-Congo hemorrhagic fever virus (CCHFV) in dromedary camels and attached ticks at 3 locations in the United Arab Emirates. Results revealed a high prevalence of CCHFV-reactive antibodies in camels and viral RNA in ticks and camel serum, suggesting the virus is endemic in this country. PMID: 32097111 [PubMed - as supplied by publisher]
J. V. Camp et al.
On 1 May 2019, in response to increasing numbers of dengue fever cases in Pakistan and India, health authorities in Afghanistan heightened monitoring for the disease. As part of this increased vigilance, the Central Public Health Laboratory (CPHL) in Kabul began to broaden its investigation for possible cases of the disease, such as reviewing samples that tested negative for Crimean-Congo Hemorrhagic Fever (CCHF) to see if they were positive for dengue. The laboratory performed differential diagnosis and tests on 40 samples that had tested negative for Crimean-Congo Hemorrhagic Fever (CCHF). Between 1 October to 4 December...