Could Grains Cause Autoimmunity?

The prolamin proteins of grains— the gliadin of wheat, secalin of rye, hordein of barley, and zein of corn— initiate the small intestinal process that cause a perfect storm in our bodies. And they do so in more than one way. You could even argue that prolamin proteins are perfectly crafted to create autoimmunity. Prolamin proteins of grains are masters at molecular mimicry. The prolamin proteins have been found to trigger immune responses to a number of human proteins, including the synapsin protein of the nervous system; the transglutaminase enzyme found in the liver, muscle, brain, and other organs; the endomysium of muscle cells; and the calreticulin of virtually every cell in the body. If sequences in foreign proteins resemble sequences in a protein of the human body, a misdirected immune attack can be launched, sending antibodies, T lymphocytes, macrophages, tumor necrosis factor, and other weapons of the immune apparatus against the organ. Some targeted human proteins, such as transglutaminase and calreticulin, are ubiquitous and can therefore be associated with autoimmune inflammation of just about any organ of the body, from brain to pancreas. Molecular mimicry is not the only means by which grains provoke autoimmunity; they also do so by increasing intestinal permeability. We’ve discussed how prolamins can resist digestion. When they remain intact, they bind to the intestinal lining and initiate a unique and complex process that opens the normal in...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Autoimmunity Dr. Davis Grain Free Lifestyle Grains Grains and Grasses Wheat Belly Lifestyle Wheat Belly Success Stories Wheat Belly Total Health Wheat-Free Lifestyle Inflammation low-carb Weight Loss Source Type: blogs

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Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Cheol Woo Park, Ji Hyeon Ahn, Tae-Kyeong Lee, Young Eun Park, Bora Kim, Jae-Chul Lee, Dae Won Kim, Myoung Cheol Shin, Yoonsoo Park, Jun Hwi Cho, Sungwoo Ryoo, Young-Myeong Kim, Moo-Ho Won, Joon Ha ParkAbstractOxcarbazepine (OXC), a voltage-gated sodium channel blocker, is an antiepileptic medication and used for the bipolar disorders treatment. Some voltage-gated sodium channel blockers have been demonstrated to display strong neuroprotective properties in models of cerebral ischemia. However, neuroprotective effects and mechanisms o...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsFeature selection methods and classification techniques were applied to mine TCM syndromes. Feature selection improved the performance of the classification models. Of six algorithms, ANN had the highest accuracy of syndrome classification.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 29 November 2019Source: Practical Radiation OncologyAuthor(s): Robert A. Scranton, Saeed Sadrameli, Edward Brian Butler, Andrew Farach, Hui-Chuan Wang, Bin S. Teh, Ivo W. Tremont-Lukats, Steve H. Fung, Paolo Zanotti-Fregonara, Robert C. RostomilyAbstractStereotactic radiosurgery (SRS) or radiotherapy (SRT) is commonly used to treat brain metastasis (BM). While effective in achieving tumor control, a significant number of BM patients exhibit lesion growth on follow-up MR imaging after SRS which cannot reliably distinguish between tumor growth, radiation necrosis (RN) or a mixture of both. ...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 January 2020Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Nadja Rifaie, Fuat H. SanerAbstractAcute liver failure is defined as severe hepatic dysfunction (marked transaminases elevation, detoxification disorder (jaundice and coagulopathy with INR> 1.5)Presence of hepatic encephalopathy and exclusion of underlying chronic liver disease and a secondary cause like sepsis or cardiogenic shock.Reasons for acute liver failure includes paracetamol -and warfarin toxicity, autoimmune – and viral (mainly hepatitis B and E) hepatitis, herbal and dietary supplemen...
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
ConclusionResults from our study supported the idea that the release of mPFC and NAc exosomes of CCI model has elevated the pain sensations in the subjected mice. This study will further help in designing new clinical trials, and will revolutionize the drug-induced anesthetic responses.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
We report 5 cases of tumors mimicking CMs. We compared clinical, initial radiologic features, and MRI evolution between 5 tumor mimics and 51 true hemorrhagic, sporadic, brain CM. Compared to true CM, mimic patients were older (47.0 vs. 38.3 years; p = 0.076) and more likely to have a history of primary neoplasm (60% vs 12%; p = 0.0267). Radiologically, the CM mimics demonstrated a higher likelihood of lesion enhancement on the initial diagnostic MRI (60% vs. 16.7%%; p = 0.0609). On follow-up MRI (
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Adults who experience pain are more likely to use cannabis without a prescription and have cannabis use disorder than those without pain, according to astudy published yesterday inAJP in Advance.“These results suggest that, among adults with pain, frequent nonmedical cannabis use and cannabis use disorder are growing problems,” wrote Deborah S. Hasin, Ph.D., of the New York State Psychiatric Institute and colleagues. “[T]he need remains for other interventions to manage pain that do n ot incur risk of another substance use disorder (i.e., cannabis use disorder) as an adverse treatment outcome.”Hasin...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance cannabis cannabis use disorder Deborah Hasin National Epidemiologic Survey on Alcohol and Related Conditions pain Source Type: research
CONCLUSIONS: The only sex difference was in SCM thickness. However, smaller SCMs in women did not result in less SCM SWE stiffness. We provided normative values for US-based imaging of the cervical-flexor and -extensor muscles in young and athletic men and women. PMID: 31967864 [PubMed - as supplied by publisher]
Source: Journal of Athletic Training - Category: Sports Medicine Tags: J Athl Train Source Type: research
ConclusionThere were excellent statistical connections between values of whiplash injury grade with muscle fatigue of paravertebral muscles and results of NDI questionnaire.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
CONCLUSIONS: The application of Hem-o-Lok clip during laparoscopic surgery is safe and effective. Postoperative Hem-o-Lok migration into the duodenum is rare. The treatment could be conservative in the majority of cases. PMID: 31958943 [PubMed - in process]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
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