Suspected Malignant Hyperthermia in the Setting of Hypothermic Circulatory Arrest for Type A Aortic Dissection Repair: A Case Report

We present a case of suspected MH in a patient undergoing emergent repair of a type A aortic dissection. Upon arrival at our institution, the patient had multiple signs of MH. However, no known triggering agent had been administered. Eventually, the unique physiologic changes of cardiopulmonary bypass provided strong support for the diagnosis of MH and dantrolene was administered, effectively treating the episode.
Source: A&A Case Reports - Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research

Related Links:

Publication date: 1 December 2019Source: Materials Letters, Volume 256Author(s): Liping Du, Xueyan Mao, Jiangtao Bai, Wugui Yang, Ping Yang, Tingyi Ye, Jian Wang, Wei Chen, Chunsheng WuAbstractDirected outgrowth and accelerated elongation are crucial for the neuronal regeneration and repair. Here we evaluated combined effects of nanofibrous scaffold and electrical field on the neuronal outgrowth. Aligned polycaprolactone (PCL) fibers provided a strong guidance cue for the neurite orientation, and the electrical field stimulation promoted the elongation and orientation of neurites. When two cues were applied simultaneously,...
Source: Materials Letters - Category: Materials Science Source Type: research
Publication date: Available online 17 September 2019Source: Mutation Research/Fundamental and Molecular Mechanisms of MutagenesisAuthor(s): Rebekah J. Hutcherson, Michael G. KempAbstractThe ATR protein kinase is known to protect cells from DNA damage induced during the replicative phase of the cell cycle. Small molecule ATR kinase inhibitors have therefore been developed to improve the effectiveness of DNA damage-based chemotherapy regimens aimed at killing rapidly proliferating tumor cells. However, whether ATR functions in a similar manner in non-replicating cells has not been examined and is important considering the fa...
Source: Mutation Research Fundamental and Molecular Mechanisms of Mutagenesis - Category: Cytology Source Type: research
Publication date: 17 September 2019Source: Cell Reports, Volume 28, Issue 12Author(s): Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskeySummaryMucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine lungs, we define the basic transcriptome of an activated M...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 September 2019Source: Cell Reports, Volume 28, Issue 12Author(s): Agnese Cristini, Giulia Ricci, Sébastien Britton, Simona Salimbeni, Shar-yin Naomi Huang, Jessica Marinello, Patrick Calsou, Yves Pommier, Gilles Favre, Giovanni Capranico, Natalia Gromak, Olivier SordetSummaryAlthough accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. Transcription-blocking topoisomerase I cleavage complexes (TOP1ccs) are frequent events that prime DSB production...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 17 September 2019Source: Cell Reports, Volume 28, Issue 12Author(s): Tianqi Leng, Hossain Delowar Akther, Carl-Philipp Hackstein, Kate Powell, Thomas King, Matthias Friedrich, Zoe Christoforidou, Sarah McCuaig, Mastura Neyazi, Carolina V. Arancibia-Cárcamo, Joachim Hagel, Fiona Powrie, Oxford IBD Investigators, Raphael Sanches Peres, Val Millar, Daniel Ebner, Rajesh Lamichhane, James Ussher, Timothy S.C. Hinks, Emanuele Marchi, Chris WillbergSummaryMAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examin...
Source: Cell Reports - Category: Cytology Source Type: research
Abstract Phosphorylation of DNA is a critical event for normal cell processes such as DNA replication, DNA repair and DNA recombination. It is important to develop accurate and convenient approach for the detection of kinase and inhibition. In this work, we have described a novel sensing strategy for T4 polynucleotide kinase. A single-stranded DNA probe is firstly immobilized on the surface of the electrode. After phosphorylated by target kinase, it could be ligated with amino group labeled DNA probe by certain hybridization. Denaturation process is then proceeded to release unligated DNA probes, which may help re...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Publication date: Available online 17 September 2019Source: Genes &DiseasesAuthor(s): Elam Coalson, Elliot Bishop, Wei Liu, Yixiao Feng, Mia Spezia, Bo Liu, Yi Shen, Di Wu, Scott Du, Alex Li, Zhenyu Ye, Ling Zhao, Daigui Cao, Alissa Li, Ofir Hagag, Alison Deng, Winny Liu, Mingyang Li, Rex C. Haydon, Lewis ShiAbstractWith the significant financial burden of chronic cutaneous wounds on the healthcare system, not to the personal burden mention on those individuals afflicted, it has become increasingly essential to improve our clinical treatments. This requires the translation of the most recent benchtop approaches to clin...
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research
To evaluate the anatomic integrity of rotator cuff repair performed by medialized single row and augmented by a porcine dermal patch, in comparison with a nonaugmented group.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Tags: Shoulder Source Type: research
Publication date: Available online 16 September 2019Source: Carbohydrate PolymersAuthor(s): Jiaoyan Liu, Bing Yang, Minhui Li, Jing Li, Ying WanAbstractThiolated chitosan (CS-NAC) was synthesized and the selected CS-NAC was used together with silk fibroin (SF) to produce dual network CS-NAC/SF hydrogels. The CS-NAC/SF solutions with formulated compositions were able to form hydrogels at physiological temperature and pH. Rheological measurements showed that elastic modulus of some CS-NAC/SF gels could reach around 3 kPa or higher and was much higher than their respective viscous modulus, indicating that they behaved like st...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): F. Salameh, O.E. O’Sullivan, B.A. O’Reilly
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
More News: Cancer & Oncology | Cardiology | Emergency Medicine | Gastroschisis Repair | Heart