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Wide range of cancers now linked to being overweight

Conclusion The results of this study provide further evidence for the link between increasing levels of fat and the risk of developing certain cancers. There was strong evidence for nine cancers, with another two – ovarian cancer and stomach cancer – included when comparing obesity with healthy weight. This study is important in showing the significance of fat levels and obesity in cancer risk. But there are some important things to consider: The study doesn't tell us how excess body fat might play a role in the development of certain cancers, just that there's a link. Some studies might have been missed, as the review relied on other researchers to include all the most recent and relevant studies in their meta-analyses. Other studies were statistically significant but of mixed quality, so it's possible excess fat is linked to other cancers, but the evidence was not quite as strong as for the cancers the study identified. While the findings of this study may be worrying, it's important to focus on the positives. Losing any excess weight should help reduce your risk of developing these types of cancer, as well as other chronic diseases like heart disease and type 2 diabetes. Get more advice and weight loss tips. Links To The Headlines Increased risk of 11 types of cancer linked to being overweight, researchers warn. The Guardian, February 28 2017 How being obese can increase the risk of developing 11 types of cancer including breast, stomach and bowel. ...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Source Type: news

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(Reuters) - Merck&Co Inc said on Thursday a key late-stage trial testing its blockbuster drug, Keytruda, failed to meet its main goal of extending lives of patients with a type of gastric cancer.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Rob Mooberry, now 43, was 38 when he was diagnosed with stage 4 colorectal cancer in Las Vegas, where he is a bartender. He switched to a vegan diet after chemo, and the cancer shrunk.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Brotfain E, Sebbag G, Friger M, Kirshtein B, Borer A, Koyfman L, Frank D, Bichovsky Y, Peiser JG, Klein M Abstract Upper gastrointestinal tract (GIT) surgical procedures are more likely to cause nosocomial Candida peritonitis than lower GIT procedures and they thus constitute an independent risk factor for mortality. Because of the severity of postsurgical fungal infections complications, intensivists and surgeons need to be extremely aware of their clinical importance in critically ill postsurgical intensive care unit (ICU) patients. We analyzed the clinical and microbiological data of 149 oncologic patie...
Source: International Journal of Surgical Oncology - Category: Surgery Tags: Int J Surg Oncol Source Type: research
Urothelial carcinoma of the bladder invasive into lamina propria on biopsy or transurethral resection of bladder tumor, termed “T1” disease, progresses to muscularis propria invasion in a subset of patients. Prior studies have proposed histopathologic metrics to predict progression, although methods vary widely and it is unclear which method is most robust. This poses a challenge since recent World Health Organization and American Joint Commission on Cancer editions encourage some attempt to substratify T1 disease. To address this critical problem, we analyzed T1 specimens to test which T1 quantification method...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Special Article Source Type: research
In conclusion: (1) the spectrum of gastric pathology associated with GAPPS is wider than previously reported, (2) the earliest microscopic clue is the finding of hyperproliferative aberrant pits, and (3) the dysplasia is gastric phenotype and the subsequent adenocarcinoma may follow the gastric pathway of carcinogenesis.
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
We hypothesized that there is a relationship between the preexisting pleomorphic adenoma [PA]), histologic grade of epithelial-myoepithelial carcinomas (EMCAs), and genetic alterations. EMCAs (n=39) were analyzed for morphologic and molecular evidence of preexisting PA (PLAG1, HMGA2 status by fluorescence in situ hybridization, FISH, and FGFR1-PLAG1 fusion by next-generation sequencing, NGS). Twenty-three EMCAs were further analyzed by NGS for mutations and copy number variation in 50 cancer-related genes. On the basis of combined morphologic and molecular evidence of PA, the following subsets of EMCA emerged: (a) EMCAs wi...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Mismatch repair deficient (dMMR) colorectal cancer (CRC) despite its association with poor histologic grade often has improved prognosis compared with MMR proficient CRC. Tumor budding and poorly differentiated clusters (PDCs) may predict metastatic potential of colorectal adenocarcinoma (CRC). In addition, their assessment may be more reproducible than the evaluation of other histopathologic parameters. Therefore, we wished to determine their potential as prognostic indicators in a cohort of dMMR CRC patients relative to histologic grade. We investigated the predictive value of conventional WHO grade, budding, PDC grade a...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
Undifferentiated endometrial carcinoma is an aggressive type of endometrial carcinoma that typically presents with advanced stage disease and rapid clinical progression. In contrast to dedifferentiated endometrial carcinoma, undifferentiated carcinoma lacks a concurrent differentiated (typically low-grade endometrioid) carcinoma component, though the undifferentiated component of dedifferentiated carcinoma is similar histologically and immunophenotypically to pure undifferentiated carcinoma. We recently identified 3 mutually exclusive mechanisms of switch/sucrose nonfermentable (SWI/SNF) complex inactivation (BRG1 inactiva...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
In conclusion, many cysts (25%) previously reported as hepatobiliary cystadenoma/cystadenocarcinoma are not MCNs. True MCNs are uncommon among resected hepatic cysts (11%), occur exclusively in females, are large, mostly intrahepatic and in the left lobe (72%). Invasive carcinomas are small and uncommon (6%) compared with their pancreatic counterpart (16%). Recurrences are not uncommon following incomplete excision.
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
In this study, we compared fresh frozen, formalin-fixed paraffin-embedded (FFPE), and PAXgene-fixed paraffin-embedded (PFPE) tissue preparation methods in radical prostatectomy prostate tissue from 36 patients and performed a preliminary test of feasibility of using PFPE tissue in routine prostate surgical pathology diagnostic assessment. In addition to comparing histology, immunohistochemistry, and general measures of DNA and RNA integrity in each fixation method, we performed functional tests of DNA and RNA quality, including targeted Miseq RNA and DNA sequencing, and implemented methods to relate DNA and RNA yield and q...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
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