Wide range of cancers now linked to being overweight

Conclusion The results of this study provide further evidence for the link between increasing levels of fat and the risk of developing certain cancers. There was strong evidence for nine cancers, with another two – ovarian cancer and stomach cancer – included when comparing obesity with healthy weight. This study is important in showing the significance of fat levels and obesity in cancer risk. But there are some important things to consider: The study doesn't tell us how excess body fat might play a role in the development of certain cancers, just that there's a link. Some studies might have been missed, as the review relied on other researchers to include all the most recent and relevant studies in their meta-analyses. Other studies were statistically significant but of mixed quality, so it's possible excess fat is linked to other cancers, but the evidence was not quite as strong as for the cancers the study identified. While the findings of this study may be worrying, it's important to focus on the positives. Losing any excess weight should help reduce your risk of developing these types of cancer, as well as other chronic diseases like heart disease and type 2 diabetes. Get more advice and weight loss tips. Links To The Headlines Increased risk of 11 types of cancer linked to being overweight, researchers warn. The Guardian, February 28 2017 How being obese can increase the risk of developing 11 types of cancer including breast, stomach and bowel. ...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Source Type: news

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In this study, we have systematically reviewed the relationships between KS and the cardiovascular system and the management of cardiovascular complication. In summary, patients with KS display increased cardiovascular risk profile, characterized by increased prevalence of metabolic alterations including dyslipidemia, diabetes mellitus (DM), and abnormalities in biomarkers of cardiovascular disease. KS subjects are characterized by subclinical abnormalities in endothelial function and in left ventricular (LV) systolic and diastolic function, which - when associated with chronotropic incompetence - may negatively influence ...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Authors: Draelos ZD, Gunt H, Levy SB Abstract Background: Rosacea is characterized by irritation associated with erythema, telangiectasias and papules/pustules. Whole formula nature-based sensitive skin products are formulated to maintain skin barrier and appropriate hydration that can lead to soothing benefits. Objective: To evaluate the efficacy and tolerability of a regimen consisting of a cleanser containing natural oils, beeswax, and witch hazel and day and night creams containing natural oils, glycerin, and botanical anti-inflammatories (NR); and a synthetic dermatologist-recommended regimen of cetyl alcohol...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Publication date: Available online 23 February 2019Source: Advances in Biological RegulationAuthor(s): Alice Domenichini, Jeanne S. Edmands, Aleksandra Adamska, Romana-Rea Begicevic, Silvano Paternoster, Marco FalascaAbstractCancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attract interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the characteristi...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: Available online 22 February 2019Source: Carbohydrate PolymersAuthor(s): Elham Gholibegloo, Tohid Mortezazadeh, Fatemeh Salehian, Ali Ramazani, Massoud Amanlou, Mehdi KhoobiAbstractA novel β-cyclodextrin-based nanosponge (CDNS) was proposed as curcumin (CUR) delivery system improving pharmacokinetics and anticancer activity of CUR. The effect of molar ratio of Epiclon (EPI) as cross-linker and β-cyclodextrin (βCD) on the porosity, surface area, swelling ratio, CUR solubility and loading capacity, rate of drug release and selective toxicity of the CDNSs was fully investigated. The high degre...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 22 February 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Mojtaba Falahati, Farnoosh Attar, Majid Sharifi, Thomas Haertlé, Jean-François Berret, Rizwan Hasan Khan, Ali Akbar SabouryAbstractNanoparticle (NP)–protein complexes exhibit the “correct identity” of NP in biological media. Therefore, protein–NP interactions should be closely explored to understand and to modulate the nature of NPs in medical implementations. This review focuses mainly on the physicochemical parameters such as dimension, surface chemistry, the mo...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Publication date: 15 May 2019Source: Sensors and Actuators B: Chemical, Volume 287Author(s): Yongfei Huang, Yongbin Zhang, Fangjun Huo, Jianbin Chao, Caixia YinAbstractThe reactive oxygen species (ROS) including hypochlorous acid (HOCl), on the one hand they can regulate physiological function in our living organisms, on the other hand abnormal concentration of ROS would induce a series of biomacromolecules damage and further endanger virtually all aspects of human health. Especially it can be directly related to cancer. Thus to elucidate and visualize their concentration is very imminent. Before many fluorescent probes we...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 22 February 2019Source: Reactive and Functional PolymersAuthor(s): Liora Colobatiu, Alexandru Gavan, Andrei Mocan, Catalina Bogdan, Simona Mirel, Ioan TomutaAbstractIn the present study, a Quality by Design (QbD) approach was applied in order to develop and optimize a chitosan film formulation loaded with bioactive compounds, intended for further use as an aid in the acceleration of wound healing. Chitosan was chosen as film forming polymer, polyethylene glycol was used as plasticizer, while polyvinyl alcohol was added to improve the bioadhesive properties of the films. Risk assessment st...
Source: Reactive and Functional Polymers - Category: Chemistry Source Type: research
Publication date: Available online 22 February 2019Source: Polymer TestingAuthor(s): Ruijie Han, Zhilong Wang, Yinghe Zhang, Kangmin NiuAbstractThermal stability mechanism of CeO2/graphene/phenyl silicone rubber composites (PMVQ) are investigated by means of SEM, TGA, swelling and mechanical testing. First, the degradation mean activation energy E of rubber composites with Td (the temperature of 50% weight loss, TGA) are used to analyze the action mechanism of CeO2 and graphene in thermal oxidative aging process. The results rev eal that CeO2 and graphene have joint effects on improving thermal stability of phenyl silicone...
Source: Polymer Testing - Category: Chemistry Source Type: research
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Chandra Shekhar Pundir, Mansi Malik, Reeti ChaudharyAbstractPyruvate (carboxylate anion of pyruvic acid) is an organic molecule, with a backbone of 3‑carbon atoms. Pyruvate is known to undergo several fates depending upon the organism under consideration. It is one of the only molecules involved in both synthesis and breakdown pathways, thereby making it a very busy molecule. Aberrant levels of this metabolite are known to cause several disorders like diabetes, cirrhosis, cardiovascular diseases and severe brain abnormalities. This is an attrac...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Abstract Although cigarette smoking is a major risk factor for lung cancer, genetic susceptibility may also affect lung cancer risk. To explore the role of genetic risk, this case-control study investigated the association between family history of cancer at several sites and lung cancer risk. A total of 1,733 lung cancer cases and 6,643 controls were selected from patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009. Information on family history of cancer was collected using a self-administered questionnaire and odds ratios (ORs) were estimated by unconditional logistic re...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
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