Exploring the cause of chronic lung transplant rejection, in a quest to stop it

Researchers have investigated the scarring process in the lungs of recent lung transplant patients in hopes of finding novel therapies to stop this dangerous process that leads to graft failure.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Histopathology, EarlyView.
Source: Histopathology - Category: Pathology Authors: Source Type: research
Voriconazole exposure and longer duration of voriconazole were found to be significantly associated with increased risk of squamous cell carcinoma. Regular dermatologic surveillance should be considered for the patients taking voriconazole, especially those at high risk of developing squamous cell carcinoma.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Transplant Infectious Disease,Volume 0, Issue ja, -Not available-.
Source: Transplant Infectious Disease - Category: Transplant Surgery Authors: Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
Condition:   Respiratory Insufficiency Intervention:   Other: Questionnaire BPI Sponsor:   Assistance Publique Hopitaux De Marseille Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplant-Related Disorder;   Frail Elderly Syndrome;   Sarcopenia;   Lung Graft Dysfunction;   Mobility Limitation Intervention:   Other: Ambulation Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Respiratory Insufficiency Intervention:   Other: Questionnaire BPI Sponsor:   Assistance Publique Hopitaux De Marseille Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Transplant-Related Disorder;   Frail Elderly Syndrome;   Sarcopenia;   Lung Graft Dysfunction;   Mobility Limitation Intervention:   Other: Ambulation Sponsor:   The Cleveland Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The diagnostic criteria for antibody-mediated rejection (AMR) after lung transplantation (LTx) includes immunohistochemistry (IHC) staining patterns for C4d but not C3d.1 Historically, C3d deposition is a recognized complication after LTx associated with primary graft dysfunction and early bronchiolitis obliterans syndrome (BOS)2,3 but is not widely used in LTx even though it's a result of complement deposition via the classical pathway.4 The International Society for Heart and Lung Transplantation Pathology Council established a threshold of>50% deposition of C4d in interstitial capillaries as diagnostic but emphasized...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
Lung donor utilization rates remain low with many organs refused for donor quality. However, certain centers have successfully transplanted these organs despite multiple refusals for donor quality (RDQ) by other centers. We hypothesize that the number of refusals due to donor quality does not impact post-transplant outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
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