Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes.

Regenerative capacity of autologous stem cell transplantation in elderly: a report of biomedical outcomes. Regen Med. 2017 Mar;12(2):169-178 Authors: Gonzalez-Garza MT, Cruz-Vega DE Abstract The occurrence of chronic diseases such as neurological, metabolic and cardiovascular degenerative disorders increases with age. Cell therapy is an emerging approach to the treatment of these conditions. Of particular interest is the application of autologous stem cells because it eliminates post-transplantation immune rejection and there are less ethical concerns associated with their use. The regenerative capacity of stem cells harvested from elderly people is however controversial. In this review, we analyze if self-renewal potential, differentiation capability and expression of stemness genes in stem cells collected from elderly patients validate their application in clinical trials and examine the results. PMID: 28244829 [PubMed - in process]
Source: Regenerative Medicine - Category: Genetics & Stem Cells Authors: Tags: Regen Med Source Type: research