Leptin, Neuroinflammation and Obesity.

Leptin, Neuroinflammation and Obesity. Front Horm Res. 2017;48:84-96 Authors: Dragano NR, Haddad-Tovolli R, Velloso LA Abstract Hypothalamic resistance to adipostatic actions of leptin is a hallmark of obesity. Studies have revealed that hypothalamic inflammation, triggered in response to the consumption of large amounts of dietary fat, is an important mechanism in the development of leptin resistance. In this chapter, we will review the work that paved the way linking neuroinflammation of the hypothalamus and defective leptin action in obesity. PMID: 28245454 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/28245454?dopt=Abstract

Source: Frontiers of Hormone Research - March 1, 2017 Category: Endocrinology Tags: Front Horm Res Source Type: research