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Abstract P4-08-02: Integration of transcriptomic, proteomic and drug response data in triple negative breast cancer cell lines and PDX models

Conclusion: According to this prospective study, kinesiotherapy and acupuncture had a positive effect on the shoulder muscle strength and quality of life of patients.Keywords: 1. Breast cancer. 2. Rehabilitation. 3. Acupuncture. 4. Muscle Strength. 5. Quality of life.Citation Format: Mills CE, Hafner MA, Sorger PK. Integration of transcriptomic, proteomic and drug response data in triple negative breast cancer cell lines and PDX models [abstract]. In: Proceedings of the Thirty-Ninth Annual CTRC-AACR San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P4-08-02.
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research

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CONCLUSIONS: Different HRQoL instruments produce notably different HRQoL scores. The EQ-5D has a pronounced ceiling effect. Pain and fatigue are the most common symptoms associated with poor HRQoL in all disease states. PMID: 29140139 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
People receiving chemotherapy are often plagued by insomnia at night and excessive drowsiness during the day. But a new study in the journal Cancer suggests that yoga can help. Breast cancer patients in the study who practiced at home at least twice a week reported better sleep quality over time, compared to those who practiced less often or not at all. The new research is “another piece of evidence, along with now dozens of studies, showing that incorporating a mind-body practice within conventional cancer care can help decrease side effects for patients,” says lead author Lorenzo Cohen, director of the integr...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Alternative Medicine Breast Cancer breast cancer treatment breathing exercises chemotherapy Exercise/Fitness fatigue insomnia Meditation sleep tibetan yoga TIME Health Breast Cancer Source Type: news
ConclusionsOur nurse‐led psychological intervention programme might reduce patients’ uncertainty and encourage them to be proactive and self‐controllable. Relevance to clinical practiceNurse‐led psychological intervention programmes should be implemented to reduce psychological distress and improve quality of life in patients with breast cancer, particularly those at a high risk of depression.
Source: Journal of Clinical Nursing - Category: Nursing Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsOur nurse‐led psychological intervention program might reduce patients’ uncertainty and encourage them to be pro‐active and self‐controllable. Relevance to clinical practiceNurse‐led psychological intervention programs should be implemented to reduce psychological distress and improve quality of life in patients with breast cancer, particularly those at a high risk of depression.This article is protected by copyright. All rights reserved.
Source: Journal of Clinical Nursing - Category: Nursing Authors: Tags: Original Article Source Type: research
We examined the prevalence, severity, and nature of subjective sleep complaints in women surviving stage I-III breast cancer who were 1-10 years posttreatment. We also examined the demographic, medical, physical, and psychosocial correlates of poor sleep in these women in order to identify the subgroups that may be most in need of intervention. METHOD: A total of 200 patients at a comprehensive cancer center who were 1-10 years posttreatment for primary stage I-III breast cancer with no evidence of disease at the time of enrollment completed a battery of questionnaires on demographics, sleep, physical symptoms, mood, ...
Source: Palliative and Supportive Care - Category: Palliative Care Authors: Tags: Palliat Support Care Source Type: research
The Journal of Alternative and Complementary Medicine , Vol. 0, No. 0.
Source: The Journal of Alternative and Complementary Medicine - Category: Complementary Medicine Source Type: research
I might have mentioned before that I have problems sleeping. This isn't new. I have had problems sleeping since my 30s. But its only recently that it has gotten much more complicated than just a bit of insomnia. Add in things like:Back pain so it can be really hard to get comfortable to sleep at all.Fibromyalgia which causes both fatigue and insomniaRheumatoid painSleep apnea and an evil CPAP machine which keeps me awakeShould I go on? I can....In the past, I have been known to get up and wash the dishes and clean the kitchen in the middle of the night because I couldn't sleep. Trust me, I have been all over the house doin...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: lack of sleep Source Type: blogs
Background: Poly(ADP-ribose) polymerase (PARP) inhibitors block DNA damage repair and may thereby enhance the clinical activity of DNA-damaging chemotherapy. Homologous recombination is defective in BRCA1/2-mutated tumors, leading to more error-prone mechanisms of DNA repair and increased sensitivity to PARP inhibition. V is a potent PARP inhibitor that enhances the antitumor activity of platinum agents in preclinical models. This phase 2 trial (NCT01506609) investigated the safety and efficacy of V+C/P or V+ temozolomide (TMZ) vs Plc+C/P in pts with locally recurrent or metastatic breast cancer harboring a BRCA1 or BRCA2 ...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: General Session Abstracts Source Type: research
Abstract A better understanding of cancer related insomnia and its relationship with other associated factors is necessary to improve its management. To clarify the relationship between insomnia and treatment related variables, sociodemographic data, health related fitness, pain, anxiety, and depression in breast cancer patients. One hundred twenty‐three patients participated in this cross‐sectional study. As a primary variable was insomnia using The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 version. Other variables included: stage of treatment, type of treatment, ...
Source: The Breast Journal - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
(University of Pennsylvania School of Medicine) For many of the 2.8 million survivors in the United States, the price of survival includes severe physical and psychosocial symptoms -- including joint pain, fatigue, weight gain and insomnia -- that may go untreated and persist for many years after treatment. Long-term survivors report an average three symptoms for which they desire more help than they are receiving, according to new research. Results of the study will be presented on Friday at the 2016 San Antonio Breast Cancer Symposium (poster P5-13-12).
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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