Abstract P3-08-01: TruRisk(R) based next-generation sequencing in BRCA1/2-negative breast and ovarian cancer families reveal high mutation prevalence in additional risk genes

Background: Studies have demonstrated that use of hormone replacement therapy (HRT) in post-menopausal women results in increased breast density. This is associated with increased risk of breast cancer and reduced sensitivity of mammography. The purpose of the present study was to compare breast densities of women following surgical menopause with and without use of HRT to women who had natural menopause without use of HRT.Methods: Our institutional Database was queried for post-menopausal women newly diagnosed with breast cancer from 01/2010 to 01/2016. Patients were divided into following groups: 1) natural menopause with no HRT use, 2) history of a bilateral salpingo-oophorectomy (BSO) with no HRT use, 3) history of a BSO with HRT use prior to diagnosis, or 4) history of BSO and use of HRT at the time of diagnosis. BSO may have occurred with or without concurrent hysterectomy.Results: 1106 women were eligible for analysis. 976 (88%) had natural menopause with no HRT, 63 (6%) had a BSO with no HRT, 51 (5%) had a BSO with previous history of HRT, and 16 (1%) had a BSO and were using HRT at time of malignancy diagnosis. Though not statistically significant, women who had a prior BSO and were on HRT at the time of diagnosis had more dense breasts (69% heterogeneously or extremely dense) than women who had natural menopause with no HRT (44% heterogeneously or extremely dense). However, women who had a prior BSO and were on HRT in the past had significantly less dense breasts (p...

Source: Cancer Research - February 13, 2017 Category: Cancer & Oncology Authors: K Keupp, L Richters, L Bulow, S Krober, C Ernst, B Blumcke, B Versmold, A Waha, J Driesen, A Baasner, J Altmuller, H Thiele, P Nuernberg, B Wappenschmidt, G Neidhardt, K Rhiem, R Schmutzler, E Hahnen, J Hauke Tags: Poster Session Abstracts Source Type: research