Abstract P2-04-10: High-affinity activated natural killer (haNK) cells augment trastuzumab efficacy in a mouse model of HER2-positive human metastatic breast cancer

Purpose: Radiation therapy is an important treatment modality in the curative management of early stage breast cancer. With increasing cancer survivorship, late effects of cancer treatment have become increasingly relevant. Breast fibrosis is a common late effect following therapeutic irradiation which can potentially result in pain, poor cosmesis, and functional impairment. Randomized trials have suggested that radiation fibrosis may be reversible or preventable using a medication regimen of Pentoxifylline and Vitamin E. These clinical trials have shown excellent patient compliance and tolerability of this regimen, but it is unclear if this tolerability translates to clinical practice. The goal of this study is to investigate the clinical tolerability and compliance with pentoxifylline and Vitamin E therapy in patients with radiation induced breast fibrosis while determining possible correlates to discontinuation.Methods: We identified ninety patients who were prescribed Pentoxifylline (400mg three time daily) and Vitamin E (400 IU once daily) following definitive breast radiation therapy from January 2013 to December 2015. A retrospective cohort study was conducted utilizing medical record analysis. Data was collected including patient age, comorbid conditions, concurrent medications, duration of pentoxifylline and Vitamin E therapy, any dose adjustments, patient reported side effects, and any reported reason for discontinuation. Multivariate analysis of correlation between...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research