Abstract ES8-1: ES8-1 Managing the aftermath of estrogen deprivation in survivors
Endocrine therapy is the most important systemic treatment for women with hormone receptor-positive breast cancer, resulting in substantial risk reduction and improvements in survival. Yet, the strategies to reduce or block estrogen including ovarian suppression or ablation, aromatase inhibition or tamoxifen can all lead to symptoms and long-term toxicities associated with estrogen deprivation. The effect of long-term estrogen deprivation on bone, heart and brain health may lead to substantial morbidity and should be considered when making treatment decisions and managed in follow-up. However, even less serious daily symptoms including hot flashes, mood changes, insomnia, weight gain, vaginal dryness and sexual dysfunction can lead to profound negative long term effects on a patient and her relationships. Thus even these more minor concerns should be considered and managed proactively for patient overall health and well-being. For serious co-morbidity risks, attention to optimizing risk factors and monitoring when appropriate (e.g., DEXA scan) is prudent. For symptom management, it is generally recommended that survivors forgo estrogen replacement therapy although sometimes a low dose, short course of replacement therapy is necessary. Otherwise, strategies include a multi-prong approach focusing not only on improving particular symptoms, but also on mitigating the downstream effects and emotional impact. Evidence-based strategies for management of vaginal dryness, hot flashes...
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Zhengzheng Xu, Guangzhe Ge, Bao Guan, Zhentao Lei, Xueyu Hao, Yuanyuan Zhou, Yue Shi, Huan Lu, Jilu Wang, Ding Peng, XiKang Wu, Huiying He, Bao Zhang, Xuesong Li, Liqun Zhou, Weimin Ci
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Pirus Ghadjar, Thomas Wiegel
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Elise De Bleser, Piet Ost
ConclusionsTattooing of axillary LNs is safe and easily performed. Tattooing was helpful in identifying the marked LN in the majority of cases. This technique helps to ensure that metastatic LNs are identified and removed at surgery after NAT.
Individuals who have multiple close relatives with pancreatic cancer should undergo surveillance for pancreatic cancer, according to updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.Reuters Health Information
Publication date: Available online 16 November 2019Source: Gynecologic Oncology ReportsAuthor(s): Hermineh Aramin, Pratistha Koirala, Abhishek Shah, Kendall Adams, Natalia Buza, Sapna Desai, Melissa Fairbairn, David Goldenberg, Wenli Gao, Linus Chuang, Ramapriya Vidhun, Vaagn Andikyan
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Ali Dehshahri, Milad Ashrafizadeh, Elham Ghasemipour Afshar, Abbas Pardakhty, Ali Mandegary, Reza Mohammadinejad, Gautam SethiAbstractTopoisomerase enzymes have shown unique roles in replication and transcription. These enzymes which were initially found in Escherichia coli have attracted considerable attention as target molecules for cancer therapy. Nowadays, there are several topoisomerase inhibitors in the market to treat or at least control the progression of cancer. However, significant toxicity, low solubility and poor pharm...
Publication date: Available online 16 November 2019Source: Journal of Evidence Based Dental PracticeAuthor(s): Walter J. Psoter, Erin T. Shope
ConclusionWithin the limitations of the study, GBR with or without autogenous block graft may be an effective approach in augmenting horizontally deficient mandibular or maxillary ridges, before the placement of dental implants. However, more complications may be seen with the use of an autogenous block graft related to the donor sites.
ConclusionsOral HPV infection is significantly prevalent and widespread worldwide, particularly among men and among populations at risk. Prevalence has increased during the last two decades.