Variability in Reexcision Following Breast Conservation Surgery
Interview with Laurence E. McCahill, MD, author of Variability in Reexcision Following Breast Conservation Surgery
Previously, we demonstrated that lumpectomy (L) patients reported higher appearance satisfaction (AS), appreciation of a pleasurable breast caress (PBC), and persistence of the breast during intimacy (BI) than mastectomy with reconstruction (MR) which we used to describe breast specific sensuality (BSS). Our current objective is to compare BSS between L and nipple-sparing mastectomy (NSM).
Abstract PURPOSE: To develop recommendations for management of patients with breast cancer (BC) with germline mutations in BC susceptibility genes. METHODS: The American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology convened an Expert Panel to develop recommendations based on a systematic review of the literature and a formal consensus process. RESULTS: Fifty-eight articles met eligibility criteria and formed the evidentiary basis for the local therapy recommendations; six randomized controlled trials of systemic therapy met eligibility criteria. ...
ConclusionThe re-excision rate following NAC is almost twice that of patients who underwent primary operative management. Her2+ and triple-negative tumors have lower re-excision rates and may represent a selected cohort most suitable for BCS. Patients with invasive lobular carcinoma or ER+ disease have significantly higher rates of margin positivity, and these patients should be considered for a cavity shave during prim ary surgery to reduce the rates of re-excision.
ConclusionsDespite similar long-term efficacy and safety profile, the higher breast conservation rate in the TC6 group suggests that preoperative chemotherapy without an anthracycline may benefit patients with HR-positive HER2-negative BC.Trial registrationUMIN000003283https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000003873.
CONCLUSIONS: Chest wall artery perforator-based flaps are an excellent option for lateral and inferior quadrant partial breast reconstructions. The short and long-term surgical outcomes are comparable across sites and can be performed with minimal morbidity. Patient-reported outcome measures need to be studied. PMID: 32203992 [PubMed]
Several studies have reported the use of acellular dermal matrix in breast reconstruction. However, the primary role of acellular dermal matrix in these studies was to support the implant; there are no reports...
Publication date: Available online 20 March 2020Source: Practical Radiation OncologyAuthor(s): Audree B. Tadros, Tracy-Ann Moo, Emily C. Zabor, Erin F. Gillespie, Atif Khan, Beryl McCormick, Oren Cahlon, Simon N. Powell, Robert Allen, Monica Morrow, Lior Z. Braunstein
CONCLUSION: RT as routine part of BCT, chemotherapy, and hormonal therapy independently exerted a mitigating effect on the risk for the development of RR. The three methods at least halved the risk. PMID: 32198570 [PubMed - as supplied by publisher]
Conclusion: Breast-conserving surgery and radiation therapy prove to be an appropriate treatment option for breast cancer patients in terms of overall survival and disease-free survival when indicated. PMID: 32181017 [PubMed - in process]
CONCLUSIONS: RFA after lumpectomy is a reliable, safe and successful procedure to obtain tumor-free surgical margins and to decrease the reoperation rate without affecting complications or compromising cosmetic results. PMID: 32192688 [PubMed - as supplied by publisher]