Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis

Conclusions</div>RIC significantly reduces infarct size in <span style="font-style:italic;">in vivo</span> models of myocardial IRI. Heterogeneity between studies could not be explained by the experimental variables tested, but studies are limited in number and lack consistency in quality and study design. There is therefore a clear need for more well-performed <span style="font-style:italic;">in vivo</span> studies with particular emphasis on detailed characterization of RIC protocols and investigating the potential impact of gender. Finally, more studies investigating the potential benefit of RIC in larger species are required before translation to humans.</span>
Source: Cardiovascular Research - Category: Cardiology Source Type: research