Sensitized signalling between L-type Ca 2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes

Conclusion:FKBP12.6 keeps the RyRs from over-sensitization, stabilizes the potentially regenerative CICR system, and thus may suppress the life-threatening arrhythmogenesis.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Conclusions: Current randomized evidence showed that continuous IV administration of epinephrine as inotropic/vasopressor agent is not associated with a worse outcome in critically ill patients.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Review Articles Source Type: research
Conclusions: Esophageal stimulation via a special feeding catheter did not improve nutritional adequacy and was associated with increase risk of harm in critically ill patients.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
Publication date: Available online 13 February 2020Source: Journal of Clinical NeuroscienceAuthor(s): Takashi Shimoyama, Hiroshi Hayashi, Fumiaki Suzuki, Yasuhiro Nishiyama, Yoshihiro Miyamoto, Takeshi Aiba, Wataru Shimizu, Kazumi KimuraAbstractMyotonic dystrophy type 1 (DM1) is an autosomal dominant inherited muscular dystrophy caused by an expanded CTG repeat in the dystrophia myotonica protein kinase (DMPK) gene. Cardiac involvements in DM1 are characterized by cardiac conduction delays and atrial or ventricular tachycardia, which increase the risk of sudden cardiac death when compared with general population. Only a fe...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionsICD placement in CS is associated with high incidence of both appropriate and inappropriate therapy. High degree AV block appears to be predictive of appropriate ICD therapy.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
In conclusion, CV decrease is not sufficient to promote arrhythmias; enlargement of atrial surface is essential to create a substrate for acute reentry-based arrhythmias.
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research
A Yale doctor successfully treated a 10-year-old dancer who had a congenital heart condition that causes abnormally quick heartbeats.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
Conclusion: Ventricular ablation lesions visualization is negatively affected by preexisting transmural scar, ICD artifact and low EF. The transition of “black” MVO appearance to “white” LGE appearance on CMR occurs around 1 month following ablation, suggesting a change in histological characteristics of ablation lesions. This may affect the utility of CMR in the evaluation of the ventricular lesions, when undergoing real‐time or repeat VT ablations.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
AbstractIntroductionAblation of outflow tract premature ventricular contractions (PVCs) is generally safe and effective. In some patients, successful ablation sites may not correlate with earliest activation.We sought to evaluate mechanistic and anatomic relevance of the region below the left sinus of Valsalva in variable morphology outflow tract ventricular arrhythmias.MethodsPVC cases where ablation was in the region inferior to the left sinus of Valsalva were identified. Procedural and demographic information, and long ‐term outcomes were obtained. Cadaver dissections to evaluate regional anatomy were done as well.Res...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Publication date: April 2020Source: Biomedical Signal Processing and Control, Volume 58Author(s): Haoren Wang, Haotian Shi, Ke Lin, Chengjin Qin, Liqun Zhao, Yixiang Huang, Chengliang LiuAbstractAs an important arrhythmia detection method, the electrocardiogram (ECG) can directly reflect abnormalities in cardiac physiological activity. In view of the difficulty in the diagnosis of arrhythmia in different people, automatic arrhythmia detection methods have been studied in previous works. In this paper, we present a dual fully-connected neural network model for accurate classification of heartbeats. Our method is following t...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Left ventricular noncompaction (LVNC) cardiomyopathy is a rare type of cardiomyopathy which occurs when the left ventricle fails to undergo compaction during embryogenesis. This results in a two layered ventricular wall, with a thinner compact epicardial layer and an inner noncompacted endocardial layer with large trabeculations. 1 It is often genetic in aetiology. A key difference compared to other cardiomyopathies is the increased risk of arrhythmias. Arrhythmias are associated with a poor prognosis due to ventricular failure, thrombo-embolic events and sudden death.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Tags: Correspondence Source Type: research
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