Sensitized signalling between L-type Ca 2+ channels and ryanodine receptors in the absence or inhibition of FKBP12.6 in cardiomyocytes

Conclusion:</div>FKBP12.6 keeps the RyRs from over-sensitization, stabilizes the potentially regenerative CICR system, and thus may suppress the life-threatening arrhythmogenesis.</span>
Source: Cardiovascular Research - Category: Cardiology Source Type: research