Hand Ground Nanoscale Zn(II)-Coordination Polymers Derived from NSAIDs: Cell Migration Inhibition of Human Breast Cancer Cells.

Hand Ground Nanoscale Zn(II)-Coordination Polymers Derived from NSAIDs: Cell Migration Inhibition of Human Breast Cancer Cells. Chemistry. 2017 Feb 25;: Authors: Dastidar P, Paul M, Sarkar K, Deb J Abstract Increased level of intracellular prostaglandin E2 (PGE2) has been linked with the unregulated cancer cell migration that often leads to metastasis. Non-steroidal-anti-inflammatory-drugs (NSAIDs) are known inhibitors of cyclooxygenase (COX) enzymes responsible for increased PGE2 concentration in inflammated as well as cancer cells. In this article, we demonstrated that NSAID derived Zn(II)-coordination polymers were able to inhibit cell migration of human breast cancer cells. Various NSAIDs were anchored to a series of 1D Zn(II)-coordination polymers via carboxylate-Zn coordination and fully characterized by single crystal X-ray diffraction. Hand grinding in laboratory mortar and pastel resulted in nano-scale coordination polymers, for the first time, suitable for biological studies. Two such hand ground nano-scale coordination polymers namely NCP1a and NCP2a containing naproxen (a well-studied NSAID) were successfully internalized within the human breast cancer cells MDA-MD-231 as evident from cellular imaging using fluorescence microscope, were able to kill the cancer cells (MTT assay) more efficiently than the corresponding mother drug naproxen and most importantly inhibited significantly the cancer cell migration thereby displa...
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research