The Future of Intravascular Imaging: Are We Primed to Detect Vulnerable Plaques?
AbstractPurpose of ReviewAtherosclerotic plaque rupture remains the primary mechanism resulting in myocardial infarction and death. Better detection of the vulnerable atherosclerotic plaque, one which is at “high risk” of rupturing, will allow earlier and more effective intervention to preventing myocardial infarction in susceptible patients. In the following manuscript, we review recent developments in the assessment of vulnerable plaque via invasive imaging. The evidence, limitations, and future prospects of various intravascular imaging modalities (optical coherence tomography (OCT), intravascular ultrasound (IVUS), angioscopy, and near-infrared spectroscopy (NIRS)) are summarized.Recent FindingsThe vulnerable plaque has unique signature depending on the imaging modality used in the diagnostic process. We show illustrative examples from every modality and we shed light on emergent technologies, aiming at providing the reader with an understanding of the interaction between modalities. We also present the concept of three-dimensional plaque assessment and explore the role of invasive imaging in helping to understand the most recently identified mechanism of stent failure: neoatherosclerosis.SummaryAs all these invasive imaging modalities have proven to be safe and feasible, recent efforts have focused on software development aiming at increasing the ease of use of these technologies, allowing faster and more accurate online display of images, and one can forecas...
ConclusionsThis case demonstrates the efficacy of compression therapy in managing post-catheterization radial artery pseudoaneurysm in patients with high bleeding risk.
In this study, we used immunoassays, transmission electron microscopy and cardiac ultrasound to confirm that p27 haploinsufficiency prevents myocardial apoptosis by restoring autophagy protein 5‑mediated autophagy flux in the early stages of MI. The present study provides a novel method for studying MI or ischemic heart disease therapy. PMID: 31485654 [PubMed - as supplied by publisher]
ConclusionIVUS-guided DES implantation should be the standard of care as it significantly reduced cardiovascular mortality and TLR.
CONCLUSIONS: Compared to 6-Fr sheath, 7-Fr sheath did not increase short-term or long-term incidence of RAO after TRI. PMID: 31478556 [PubMed - as supplied by publisher]
Intravascular imaging (intravascular ultrasound, IVUS and optical coherence tomography, OCT) are recommended tools to optimize stent placement during percutaneous coronary intervention (PCI).1 The use of intravascular imaging is increasing among patients undergoing PCI for non-ST elevation myocardial infarction (NSTEMI).2 Data on temporal trends of intravascular imaging use in the setting of ST elevation myocardial infarction (STEMI) are unknown. We performed this study to analyze trends of intravascular imaging for PCI in setting of STEMI.
Condition: ST Elevation Myocardial Infarction Interventions: Procedure: IVUS-guided PCI; Procedure: Angiography-guided PCI Sponsors: Second Affiliated Hospital, School of Medicine, Zhejiang University; Ningbo No. 1 Hospital Not yet recruiting
Background: Stem cell therapy of acute myocardial infarction is proving to be a promising approach to repair the injured myocardia. However, the time window for stem cell transplantation is important and yet difficult to determine since it produces much different therapeutic effect at different times after myocardial infarction. Stromal cell-derived factor-1 (SDF-1) plays a pivotal role in the mobilization, homing, proliferation and differentiation of transplanted stem cells. Here, by using of ultrasound molecular imaging via targeted microbubbles, we determined the dynamic expression of SDF-1 in a swine model of acute myo...