B cells produce antibodies 'when danger calls, but not when it whispers,' scientists report
The immune system’s B cells protect us from disease by producing antibodies, or "smart bullets," that specifically target invaders such as pathogens and viruses while leaving harmless molecules alone. But how do B cells determine whether a threat is real and whether to start producing these weapons? An international team of life scientists shows in the May 16 issue of the journal Science how and why these cells respond only to true threats. "It is critical for B cells to respond either fully or not at all. Anything in between causes disease," said the study’s senior author, Alexander Hoffmann, a professor of microbiology, immunology and molecular genetics in the UCLA College of Letters and Science. "If B cells respond wimpily when there is a real pathogen, you have immune deficiency, and if they respond inappropriately to something that is not a true pathogen, then you have autoimmune disease." The antibodies produced by B cells attack antigens — molecules associated with pathogens, microbes and viruses. A sensor on the cell’s surface is meant to recognize a specific antigen, and when the sensor encounters that antigen, it sends a signal that enables the body’s army of B cells to respond rapidly. However, there may be similar molecules nearby that are harmless. The B cells should ignore their signals — something they fail to do in autoimmune diseases. So how do the B cells decide whether to start pro...
(MedPage Today) -- Peter Ubel, MD, explains how to let older patients know tests won't help
A preplanned analysis of ctDNA found that a subpopulation of mCRC patients with acquired anti-EGFR resistance were sensitive to treatment with Sym004.
The addition of metronomic chemotherapy to dual HER2 blockade improved outcomes in older and frail patients with HER2-positive metastatic breast cancer.
Date: Wednesday, 03 21, 2018; Speaker: Charles Rabkin, M.D., Senior Investigator, Division of Cancer Epidemiology and Genetics, NCI; https://epi.grants.cancer.gov/events
Date: Thursday, 03 29, 2018; Speaker: Cassandra Harris, M.S., M.C.H.E.S., Manager, Health Education, MD Anderson Cancer Center; Kathi Ridley-Merriweather, M.A., Communications and Minority Outreach Coordinator, Komen Tissue Bank; Ren é Arnold, M.B.A., Former Operations Manager, The Fountain of Praise Church; https://epi.grants.cancer.gov/events/enrich-forum/
The Wayne D. Kuni&Joan E. Kuni Foundation has awarded $5 million to Legacy Health Foundation to found a cancer research project. The grant will fund research into how cancer can be targeted by manipulating adenosine kinase, an enzyme that controls cell growth. The research is led by Detlev Boison, Dow Chair of Neurology and director of neurobiology research and basic and translational research at Legacy Research Institute; and Dr. Serene Perkins, director of surgical and clinical research at…
A biologic under investigation for severe psoriasis has topped one of the most effective therapies on the market in head-to-head phase 3 trials.Medscape Medical News
By the end of the study, 67 percent of the participants who took the peanut flour were able to tolerate the equivalent of roughly two peanuts, compared with only 4 percent of those who took the placebo.
Conclusion Recent evidence shows changes in frequency and function of Th22 and its cytokine IL-22 in patients with MS, which suggests a potential relationship between Th22 cells, IL-22 levels, and the development and disease course of MS and its response to treatment. How Th22 cells and IL-22 levels affect the disease course of MS requires further elucidation. Additional studies on the immunopathogenesis of MS, specifically the roles Th22 cells and IL-22 cytokines may play in disease progression, are warranted and may lead to the development of new therapeutic strategies for treating neuro-inflammatory diseases, such as MS...
Conclusion A growing number of today’s children suffer from vaccine damage. Most individuals do not make the connection between health problems and vaccines. When asked about the cause of autoimmune disorders, asthma, allergies, diabetes, learning disabilities, attention deficit disorder, autism, and other common childhood diseases and illness, the majority of health care providers advise patients that the causes are unknown. Doctors, including most integrative physicians, fail to make the connection to vaccines. It takes one moment to permanently damage the health of an adult or child, but t...
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