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NLM Technical Bulletin, May-Jun 2014, New Clinical Advisory Issued by National Heart, Lung, and Blood Institute

The National Institutes of Health’s National Heart, Lung, and Blood Institute has suspended enrollment for the clinical study BMT CTN 0901 conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) after preliminary data appeared to show benefit for one approach to the intensity of conditioning for allogeneic stem cell transplantations in patients eligible for the study.
Source: NLM Technical Bulletin - Category: Databases & Libraries Source Type: news

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This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition. In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conditions:   Severe Aplastic Anemia (SAA);   Hypo-Plastic Myelodysplastic Syndrome (MDS) Intervention:   Procedure: haplo-identical transplantation Sponsor:   National Heart, Lung, and Blood Institute (NHLBI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We describe our unique approach of aiming for ASCT one year after HT so that patients can remain in hematological remission with current chemotherapy and to allow patients complete recovery from OHT.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Heart transplantation remains the standard treatment for end stage heart failure patients. However, hemodynamic instability after brain death (BD) could affect posttransplant graft function. Conditioned medium (CM) from bone marrow derived mesenchymal stem cells (MSCs) was found to protect the myocardium against ischemia/reperfusion (IR), this finding appears to be mediated via activation of the phosphatidylinositol 3 kinase (PI3K) signalling. We hypothesized that CM added to a preservation solution (Custodiol) improves in vivo left ventricular (LV) graft function after transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Introduction: Respiratory complications of Hematopoietic Stem Cell Transplantation (HSCT), both allogeneic and autologous, comprise the majority of its morbidity and mortality. Chronic Graft Versus Host Disease (cGVHD) is a multisystem disorder that is a common complication of allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Bronchiolitis Obliterans Syndrome (BOS) considered part of the spectrum of cGVHD pulmonary manifestations, affect 5.5% of transplant recipients. The prognosis of BOS remains poor.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Pulmonary graft versus host disease (GVHD), manifest as bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis, is a serious complication of haematopoietic stem cell transplantation (HSCT) causing respiratory failure and death. There are limited therapeutic options for severe cases other than lung transplantation (LTx) but
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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