Inhibition of ROMK blocks macula densa tubuloglomerular feedback yet causes renal vasoconstriction in anesthetized rats.

In conclusion, blockade of ROMK or Na+/K+/2Cl- transport inhibits TGF yet increases renal vascular resistance. The renal vasoconstriction was independent of volume depletion, blood pressure, TGF or PPT.
PMID: 28228405 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - February 21, 2017 Category: Urology & Nephrology Authors: Araujo M, Welch WJ, Zhou X, Sullivan K, Walsh S, Pasternak A, Wilcox CS Tags: Am J Physiol Renal Physiol Source Type: research