Scientists Test Deep Brain Stimulation As Potential Anorexia Therapy
A small study in 16 people with severe anorexia has found that implanting stimulation electrodes into the brains of patients could ease their anxiety and help them gain weight. Researchers found that in extreme cases of the eating disorder, the technique - known as deep brain stimulation (DBS) - swiftly helped many of those studied reduce symptoms of either anxiety or depression, and improved their quality of life. A few months later, the improved psychological symptoms began to lead to changes in weight, the researchers said, with the average body mass index (BMI) of the group increasing to 17.3 – a rise of 3.5 points – over the course of the study. Anorexia is a serious eating disorder that affects around 0.5 percent of people worldwide, the majority of them teenage girls. Patients have persistent concerns about their weight, shape and size, and starve themselves to maintain a low weight. Chronic anorexia can be fatal, and in many cases causes severe health problems including weak bones and muscles, sexual problems, infertility, heart problems and seizures. The scientists who led this study, published in The Lancet Psychiatry journal on Friday, said their results suggest deep brain stimulation - which involves implanting electrodes to stimulate brain areas that control dysfunctional behaviors - might alter the brain circuits that drive anorexia. DBS is already used to target brain circuits involved in Parkinson’s disease and tremors - and been shown to be ...
Abstract Background: Despite recent advances that have improved the pregnancy success rates that can be achieved via in vitro fertilization (IVF) therapy, it is not yet clear which blastocyst morphological parameters best predict the outcomes of single blastocyst transfer. In addition, most of the previous studies did not exclude the effect of embryo aneuploidy on blastocysts transfer. Thus, the present study investigated the predictive value of various parameters on the pregnancy outcomes achieved via the transfer of frozen euploid blastocysts. Methods: The study retrospectively analyzed 914 single euploid b...
CONCLUSIONS: The prevalence and incidence of dementia increase exponentially from the age of 65 onwards. As a consequence of the progressive ageing of the population and the increase in life expectancy, the number of cases of dementia will rise in the coming decades. Recent studies point to a slight drop in the accumulated risk of dementia adjusted by age groups and sex over the last few decades in some countries. It is possible that by means of primary prevention strategies implemented upon the known risk factors for dementia the burden of dementia on public health will diminish in the future. PMID: 29790571 [PubMed - in process]
CONCLUSIONS: Although the typical clinical manifestations of giant cell arteritis are headache, jaw claudication, loss of sight, constitutional symptoms and polymyalgia rheumatica, its presence must be suspected in patients over the age of 50 who manifest alterations affecting the peripheral nerve, including brachial diplegia with no other demonstrable cause. PMID: 29790570 [PubMed - in process]
CONCLUSION: Treatment with ESL could improve some aspects of theory of mind in patients with epilepsy, especially in men and independently of the control of seizures, with no changes in quality of life, anxiety or depression. PMID: 29790568 [PubMed - in process]
Conclusions: Staff training and clinical support in the use of a structured clinical protocol for managing BPSD were linked to reductions in staff job stress, which may in turn increase staff capacity to identify indicators of resident distress and respond accordingly. Site variation in outcomes may relate to organisational and workforce-level barriers that may be unique to the RAC context and should be systematically addressed in future RCT studies of larger PND samples. PMID: 29785228 [PubMed - in process]
Objective: To assess the relationship of constipation and diarrhea severity during the menopause transition (MT) with age, MT stage, reproductive biomarkers, stress-related biomarkers, and stress-related perceptions. Methods: From 1990 to 1992, women aged 35 to 55 years were recruited from the greater Seattle area; 291 of them consented to ongoing (1990-2013) annual data collection by daily menstrual calendar, health diary, and annual health questionnaire. A subset (n = 131) provided a first morning voided urine specimen (1997-2013). These were assayed for levels of E1G, follicle-stimulating hormone, testosterone,...
Conclusions: Perimenopausal HIV-infected women experienced a disproportionately high level of affective symptom burden over a 12-month observation period. Given the potential for these factors to influence adherence to HIV clinical care and quality of life, careful assessment and referral for treatment of these symptoms is essential.
Ali S. Shalash, Eman Hamid, Hanan Hani Elrassas, Ahmed Safwat Bedair, Abdelrahman Ibrahim Abushouk, Mohamed Khamis, Mostafa Hashim, Nahed Salah-Eldin Ahmed, Samia Ashour, Mahmoud Elbalkimy
Manuel Men éndez-González, Tania Álvarez-Avellón, José M. Salas-Pacheco, Benito de Celis-Alonso, Kathryn A. Wyman-Chick, Oscar Arias-Carrión
Mauro Murgia, Roberta Pili, Federica Corona, Fabrizio Sors, Tiziano A. Agostini, Paolo Bernardis, Carlo Casula, Giovanni Cossu, Marco Guicciardi, Massimiliano Pau