To screen or not to screen? Celiac antibodies in liver diseases.
To screen or not to screen? Celiac antibodies in liver diseases.
World J Gastroenterol. 2017 Feb 07;23(5):776-791
Authors: Narciso-Schiavon JL, Schiavon LL
Abstract
Celiac disease (CD) is a systemic immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals. The typical symptoms are anemia, diarrhea, fatigue, weight loss, and abdominal pain. CD has been reported in patients with primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, aminotransferase elevations, nonalcoholic fatty liver disease, hepatitis B, hepatitis C, portal hypertension and liver cirrhosis. We evaluate recommendations for active screening for CD in patients with liver diseases, and the effect of a gluten-free diet in these different settings. Active screening for CD is recommended in patients with liver diseases, particularly in those with autoimmune disorders, steatosis in the absence of metabolic syndrome, noncirrhotic intrahepatic portal hypertension, cryptogenic cirrhosis, and in the context of liver transplantation. In hepatitis C, diagnosis of CD can be important as a relative contraindication to interferon use. Gluten-free diet ameliorates the symptoms associated with CD; however, the associated liver disease may improve, remain the same, or progress.
PMID: 28223722 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Narciso-Schiavon JL, Schiavon LL Tags: World J Gastroenterol Source Type: research
More News: Anemia | Autoimmune Disease | Celiac Disease | Cirrhosis | Coeliac Disease | Fatty Liver Disease (FLD) | Gastroenterology | Genetics | Hepatitis | Hepatitis B | Hepatitis C | Hypertension | Liver | Liver Disease | Liver Transplant | Metabolic Syndrome | Non-alcoholic Fatty Liver Diseases (NAFLD) | Nutrition | Pain | Transplants | Urology & Nephrology | Weight Loss