Outcomes of Pharmacokinetically Targeted Busulfan-Based Conditioning Regimen for Patients with Myelodysplastic Syndrome and Acute Myelogenous Leukemia Undergoing CD34 Selected Allogeneic Hematopoietic Stem Cell Transplantation

Introduction: Conventional allogeneic hematopoietic cell transplantation (allo-HSCT) is an established therapy for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). CD34 selected allo-HSCT has been shown to yield similar survival rates as unmodified transplant but with significantly lower incidence of acute and chronic GVHD. This type of transplant is done mostly in the context of a myeloablative conditioning (MAC) regimen and a common chemotherapy regimen is busulfan (bu), melphalan and fludarabine with ATG.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research