Prospective Assessment of Diagnostic Infectious Disease Molecular PCR Testing with Early Fiberoptic Bronchoscopy (FOB) in the Evaluation of New Pulmonary Infiltrates in Hematopoietic Stem Cell Transplantation (HSCT) and Acute Leukemia (AL) Patients (pts)

Pneumonia is a major cause of morbidity in pts undergoing HSCT and AL therapy. Early FOB with culture, cytopath and viral ELISA testing improves survival. Early FOB at our center historically identified causative microorganism(s) in 37% of pts (68/183). We conducted an IRB approved prospective early FOB trial in 49 pts undergoing HSCT or AL therapy with respiratory symptoms and new radiographic lung infiltrates to determine the impact of the rapid PCR panel combined with culture testing. The PCR panel included Mycoplasma, Chlamydia, HSV, VZV, HHV7, RSV, hMPV, Rhino/Coronavirus, Adenovirus, Influenza A/B, Parainfluenza Type 1-3 and Aspergillus.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research