Lgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancer.

In conclusions, Lgr5 over-expression might involve the proliferation, invasion, and distant and regional metastasis of CRC cells, and has potential positive relation to HER2 expression. PMID: 24817953 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/24817953?dopt=Abstract

Source: International Journal of Clinical and Experimental Pathology - May 15, 2014 Category: Pathology Authors: Gao FJ, Chen JY, Wu HY, Shi J, Chen M, Fan XS, Huang Q Tags: Int J Clin Exp Pathol Source Type: research