The changing role of TGF β in healthy, ageing and osteoarthritic joints

Nature Reviews Rheumatology 13, 155 (2017).
doi:10.1038/nrrheum.2016.219

Author: Peter M. van der Kraan
Transforming growth factor-β (TGFβ) is a pleiotropic cytokine that is important in the regulation of joint homeostasis and disease. TGFβ signalling is induced by loading and has an important function in maintaining the differentiated phenotype of articular chondrocytes. Concentrations of active TGFβ differ greatly between

Source: Nature Reviews Rheumatology - February 1, 2017 Category: Rheumatology Authors: Peter M. van der Kraan Tags: Review Source Type: research