Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice

Anthracyclines are effective anticancer drugs that have improved prognosis of hundred thousand cancer patients worldwide and are currently the most common chemotherapeutic agents used for the treatment of blood, breast, ovarian and lung cancers. However, their use is limited because of a cumulative dose-dependent and irreversible cardiotoxicity that can cause progressive cardiomyopathy and congestive heart failure. Aim of the present study was to determine the cardioprotective activity of a dietary source of cyanidin 3-glucoside (C3G), such as purple corn, against doxorubicin (DOX) -induced cardiotoxicity in mice.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - February 20, 2017 Category: Nutrition Authors: K. Petroni, M. Trinei, M. Fornari, V. Calvenzani, A. Marinelli, L.A. Micheli, R. Pilu, A. Matros, H.-P. Mock, C. Tonelli, M. Giorgio Source Type: research