Experimental infections of different carp strains with the carp edema virus (CEV) give insights into the infection biology of the virus and indicate possible solutions to problems caused by koi sleepy disease (KSD) in carp aquaculture
AbstractOutbreaks of koi sleepy disease (KSD) caused bycarp edema virus (CEV) may seriously affect populations of farmed common carp, one of the most important fish species for global food production. The present study shows further evidence for the involvement of CEV in outbreaks of KSD among carp and koi populations: in a series of infection experiments, CEV from two different genogroups could be transmitted to several strains of na ïve common carp via cohabitation with fish infected with CEV. In recipient fish, clinical signs of KSD were induced. The virus load and viral gene expression results confirm gills as the target organ for CEV replication. Gill explants also allowed for a limited virus replication in vitro. The in vi vo infection experiments revealed differences in the virulence of the two CEV genogroups which were associated with infections in koi or in common carp, with higher virulence towards the same fish variety as the donor fish. When the susceptibility of different carp strains to a CEV infection and the development of KSD were experimentally investigated, Amur wild carp showed to be relatively more resistant to the infection and did not develop clinical signs for KSD. However, the resistance could not be related to a higher magnitude of type I IFN responses of affected tissues. Despite not having a mechanistic explanation for the resistance of Amur wild carp to KSD, we recommend using this carp strain in breeding programs to limit potential losses ca...
In this study, 48 PCV2 strains were isolated in China between 2016 and 2018 and the genetic diversity of these PCV2 isolates was determined. Results showed that these PCV2 isolates were classified into genotypes PCV2a (4 of 48), PCV2b (13 of 48) and PCV2d (31 of 48). Among them, 54.5% isolated in 2016, 65.2% isolated in 2017 and 71.4% isolated in 2018 belonged to PCV2d. It indicated that the prevalence of PCV2d genotype increased. All strains shared 93.4%-100% nucleotide sequence identity for the whole genome. Results of the analysis using RDP 4.0 molecular recombination software showed there were no recombinant events amo...
This report describes how DINEPA and the US Centers for Disease Control and Prevention (CDC) collaborated to design and implement a training program for 264 potable water and sanitation technicians for rural areas. The paper also describes the initial field activities of the newly trained technicians and the immediate impact of their work in the rural water, sanitation and hygiene sector. PMID: 31798827 [PubMed]
An alleged anti-vaxxer has been charged with "incitement against the government vaccination order," the Samoan government said Thursday.
Restaurant chain's CEO touts improved-safety practices after health scares including a norovirus outbreak in 2017
Health officials investigating a nationwide outbreak of vaping illnesses have listed, for the first time, the vape brands that are most commonly linked to hospitalizations
Publication date: 7–13 December 2019Source: The Lancet, Volume 394, Issue 10214Author(s): Jo Middleton, Stephen L Walker, Thomas House, Michael G Head, Jackie A Cassel
Conclusion: Better management practices and timely reporting can reduce the risk factors associated with the disease. PMID: 31803773 [PubMed]
The United States recorded 15 measles cases over about a month as of Dec. 5, taking the total cases for the year to 1,276 in the worst outbreak since 1992, the Centers for Disease Control and Prevention said on Friday.
The disease has infected more than 4,300 people on the islands, killing at least 63 of them
Samoan government employees stopped work to administer measles vaccines in an attempt to halt an outbreak of the deadly disease sweeping the island nation