Anti-PY1235-MET Immunological Binding Reagent as Cancer Diagnostic

This technology consists of highly specific rabbit monoclonal antibodies reactive with phosphorylated tyrosine located at amino acid 1235 in the human MET sequence. Binding to this pYl235 residue is independent of the phosphorylation of other tyrosines in the vicinity (1230 and 1234), does not crossreact with these nearby phosphotyrosine residues, and does not occur when Y1235 is unphosphorylated.The receptor tyrosine kinase MET is an important drug target for treatment of various diseases including diseases mediated by dysregulated cell proliferation (e.g., cancer). A key event involved in MET activation and/or signaling is phosphorylation at the Y1235 position. However, MET activation and/or signaling is difficult to assess due to the lack of specific binding reagents that detect phosphorylation at Y1235 of MET without cross-reacting with one or more other phosphorylation sites. Inventors from NCI ’s DCTD have developed an invention that enables specific quantitation of the phosphorylation status of the 1235-tyrosine residue, which is a key post-translational modification that activates MET receptor signaling. Specific pY1235 measurement will have many useful applications including (but not limited to): 1) pharmacodynamic assessments of the molecular response of the MET receptor to inhibitors, proving target engagement, providing evidence for mechanism-of-action, developing optimized dosing schedules, and enabling proof-of-concept; 2) comparison of potency of multiple MET...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research