Advanced Primary Epithelial Ovarian and Peritoneal Carcinoma —Does Diagnostic Accuracy of Preoperative CT Scan for Detection of Peritoneal Metastatic Sites Reflect into Prediction of Suboptimal Debulking? A Prospective Study

AbstractOvarian cancer is the seventh most common cancer in females worldwide. Optimal debulking is the standard treatment but possible only in 30 –85% of advanced stages. Knowing exactly the disease extent preoperatively may predict suboptimal debulking. We analyzed diagnostic accuracy of preoperative CT scan in disease mapping and prediction of suboptimal debulking in a prospective observational study from March 2013 to May 2015 in a terti ary hospital. Adults below the age of 75 years with ECOG PS-0, 1, 2, clinically/radiologically newly diagnosed stage IIIc epithelial ovarian (EOC), and primary peritoneal carcinoma (PPC) were included. Neoadjuvant chemotherapy recipients were excluded. Preoperative multidetector CT (MDCT) scan show ing deposits at 19 predetermined abdominopelvic sites were compared with the same sites seen at laparotomy and corresponding accuracies of CT scan calculated. Primary debulking surgery was done to achieve debulking to nil or less than 1-cm residual disease. Stepwise logistic regression models were u sed to determine the frequent suboptimal debulking sites and the predictive performance of the clinical and CT scan findings. A total of 36 patients were enrolled. The optimal debulking rate was 50%. The CT scan could detect the disease-bearing sites with overall sensitivity of 68.29%, specificity o f 89%, accuracy of 78.07%, and positive and negative predictive values of 99 and 50.1%, respectively. Upon multivariate analysis, bowel mesen...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research

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In this study, 5% w/v SMP dispersion was acidified to pH 2.4–3.0 using citric acid and heated at different conditions. Lowering pH resulted in dissolution of colloidal calcium phosphate from casein micelles, corresponding to lowered turbidity and reduced hydrodynamic diameter of dispersions. When heated for 10 min at different temperatures, 70 °C was the most effective to produce transparent dispersions; whereas a shorter heating time between 2 and 60 min was desired at 90 °C. The decreased turbidity after heating was attributed to weakened hydrophobic interaction between casein molecules based on f...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
Publication date: Available online 14 October 2019Source: Food ChemistryAuthor(s): Jianghao Sun, Craig S. Charron, Janet A. Novotny, Bing Peng, Liangli Yu, Pei ChenAbstractBroccoli is a popular brassica vegetable and its consumption may decrease the occurrence of cancer in certain populations. To gain insight into the metabolites that may induce physiological responses to broccoli intake, a non-targeted metabolomic approach and a targeted approach for analysis of glucosinolate metabolites were developed using high resolution accurate mass spectrometry. A human study was conducted in which 6 subjects consumed a single meal ...
Source: Food Chemistry - Category: Food Science Source Type: research
CONCLUSION: Most CPAFs identified on CCTA have a favorable prognosis. Observation with OMT is usually an appropriate strategy. Fistula size is a possible determinant for surgical treatment. PMID: 31606954 [PubMed - in process]
Source: Korean Journal of Radiology - Category: Radiology Tags: Korean J Radiol Source Type: research
Publication date: Available online 13 October 2019Source: Journal of Molecular LiquidsAuthor(s): Hany M.Abd El-Lateef, Zeinab A. Abdallah, Mohamed S.Mohamed AhmedAbstractEthyl 2-(1,2,3,6-tetrahydro-6-oxo-2-thioxopyrimidin-4-yl)ethanoate (EOTPE) was synthesized by a facile and cost-effective method. The structure confirmation of the synthesized EOTPE was performed by different spectroscopic methods. The corrosion inhibition action of EOTPE in pickling acids (1.0 N HCl and1.0 N H2SO4) at different temperatures (30–60 °C) was tested by various surface and corrosion methods, including open circuit potential (...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: November 2019Source: Fish &Shellfish Immunology, Volume 94Author(s): Elumalai Preetham, Abdul Salam Rubeena, Baskaralingam Vaseeharan, Mukesh Kumar Chaurasia, Jesu Arockiaraj, Rolf Erik OlsenAbstractThe study is carried out to understand the antimicrobial and immunological response of a potential immune molecule lectin, MmLec isolated from haemolymph of Speckled shrimp, Metapenaeus monoceros. MmLec was purified using mannose coupled Sepharose CL-4B affinity chromatography, which was further subjected on SDS-PAGE to ascertain the distribution of their molecular weight. Sugar binding specificity assay w...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 13 October 2019Source: Advances in Biological RegulationAuthor(s): Veronica Balatti, Carlo M. CroceAbstractWe established that loss of miR-15a/16–1 genes on chromosome 13q14 is the most common alteration in Chronic Lymphocytic Leukemia (CLL) and that miR-15/16 are crucial negative regulator of BCL-2, an antiapoptotic gene overexpressed in most CLLs and in many other malignancies. We have also shown that miR-15/16 target ROR1, a cell surface receptor for Wnt5a which can enhance growth/survival of CLL cells. Interestingly, ROR1 is expressed by many cancers, but not by normal adult tis...
Source: Advances in Biological Regulation - Category: Biology Source Type: research
Publication date: 1 December 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 184Author(s): Maosheng Xu, Kunsong Zhang, Yubing Liu, Jie Wang, Ke Wang, Yuanqing ZhangAbstractThe treatment of cancer has always been a worldwide problem. The combination of chemotherapy and other therapies would be a promising therapy strategy. Photothermal therapy (PTT) does not cause serious side effects and has dual control of time and space, which was considered to be a good method for combination with chemotherapy. Here, we modified multifunctional nanosheets based on in-situ gold nanoparticles (Au NPs) grown molybdenum disulfide...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 13 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Zakie Anajafi, Mahmoud Naseri, G. NeriAbstractIn this paper, the synthesis, characterization and sensing properties of SmFeO3/ZnO nanocomposite synthesized by the thermal treatment method, is reported. The morphological and microstructural characteristics of the synthesized composite nanopowders and single SmFeO3 and ZnO components, were analyzed by Scanning Electron Microscopy-Electron Dispersive X-ray (SEM-EDX), X-ray diffraction (XRD), Fourier Transform-Infrared (FT-IR) spectroscopy and Photoluminscence (PL). Characteri...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 13 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Chenyu Yao, Limin Xiao, Shoufei Gao, Yingying Wang, Pu Wang, Ruifeng Kan, Wei Jin, Wei RenAbstractWe demonstrated the sensitive CO detection in a novel hollow-core negative curvature fiber (HC-NCF) with infrared laser absorption at 2.3 µm. The HC-NCF consists of a single ring of eight nontouching silica capillaries around the air core, providing a single-mode light delivery of the 2.3-µm distributed feedback laser. A high coupling efficiency of 90% was achieved with the aid of optimal free-space coupling...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 13 October 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Chaonan Yang, Qingfu Guo, Yan Lu, Bin Zhang, Guangming NieABSTRACTA novel “signal-on” electrochemiluminescence (ECL) immunosensor is constructed by using Au nanoparticle/graphene quantum dots-poly(etherimide)-graphene oxide (AuNP/GQDs-PEI-GO) composite as a probe to detect prostate-specific antigen (PSA). GQDs and AuNP are modified onto the PEI-GO through amide bond and electrostatic interaction sequentially. Poly(indole-6-carboxylic acid)/flower-like Au nanoparticles (PICA/FGNs) composites with satisfactory co...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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