Carriers of a VEGFA enhancer polymorphism selectively binding CHOP/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone

Conclusions VEGF is an important angiogenic signal required for tissue expansion. We show that VEGFA variation giving allele-specific response to transcription factors with overlapping binding sites associate closely with circulating TSH levels. Because CHOP is induced by several types of intracellular stress, this indicates that cellular stress could be involved in the normal or pathophysiological response of the thyroid to TSH. Trial registration number NCT00289237, NCT00316667; Results.

http://jmg.bmj.com/cgi/content/short/54/3/166?rss=1

Source: Journal of Medical Genetics - February 17, 2017 Category: Genetics & Stem Cells Authors: Ahluwalia, T. S., Troelsen, J. T., Balslev-Harder, M., Bork-Jensen, J., Thuesen, B. H., Cerqueira, C., Linneberg, A., Grarup, N., Pedersen, O., Hansen, T., Dalgaard, L. T. Tags: Immunology (including allergy), Reproductive medicine, Drugs: endocrine system Functional genomics Source Type: research