Does Extracellular DNA Production Vary in Staphylococcal Biofilms Isolated From Infected Implants versus Controls?

CONCLUSIONS: S aureus and S epidermidis exhibit a differential production of DNA with time. Clinical isolates associated with implant infections produce greater amounts of eDNA than controls. Future research might focus on the diagnostic value of eDNA as a surrogate laboratory marker for biofilm formation in implant infections.
CLINICAL RELEVANCE: eDNA should be considered as a potential future diagnostic tool or even a possible target to modify biofilms for successful treatment of biofilm-associated infections.
PMID: 28194715 [PubMed - as supplied by publisher]

Source: Clinical Orthopaedics and Related Research - February 12, 2017 Category: Orthopaedics Authors: Zatorska B, Groger M, Moser D, Diab-Elschahawi M, Lusignani LS, Presterl E Tags: Clin Orthop Relat Res Source Type: research