What DNA Fragmentation May Tell Us About Recurrent Pregnancy Loss What DNA Fragmentation May Tell Us About Recurrent Pregnancy Loss

Dr Kovacs reviews a study that evaluated the degree of DNA fragmentation in men in couples with recurrent miscarriages, as compared with infertile and fertile men.Medscape Ob/Gyn
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Viewpoint Source Type: news

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ni ME Abstract Context: There is increasing evidence for MIS/AMH physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy. Objective: To investigate the association of MIS/AMH levels with risk of adverse obstetric outcomes. Design: Retrospective cohort study. Setting: Academic fertility center. Patients: Women who became pregnant through in vitro fertilization (IVF) between January 2012-October 2016. Exclusion criteria were: oocyte donation, gestational carrier, multiple gestation, miscarriage before 20 weeks, medically indicated preterm deliverie...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Increased serum C-reactive protein (CRP) levels have recently been reported to reduce fecundity in healthy eumenorrheic women with a history of 1-2 pregnancy losses. 1 As subclinical systemic inflammation may impede maternal immune tolerance, implantation and embryonic development might be compromised. Inflammation could, thus, also serve as a causative factor for the substantial proportion of miscarriages that reveal normal karyotypes after analysis of products of conception (POCs). To evaluate in infertile women the relationship between pre-pregnancy CRP levels and POC karyotype was the objective of this study.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Ovulation Induction with IUI is a common first step in the treatment of infertility given its lower cost and ease of implementation compared to IVF. Disadvantages include lower pregnancy rates and thus longer time to conception. PGT-A provides the advantage of lower miscarriage rates (SAB). We sought to compare the pregnancy outcomes and cost per cycle of IUI and IVF/ PGT-A.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Abstract OBJECTIVE: To ascertain whether stress biomarker and psychological indices of stress may predict both conception and miscarriage rates in women undergoing in-vitro fertilization/ intracytoplasmic sperm injection (IVF/ ICSI). DESIGN: Prospective observational study. SETTING: A university-affiliated tertiary hospital. POPULATION OR SAMPLE: Infertility women who were undergoing fresh or frozen IVF/ICSI cycles. METHODS: Subjects were recruited to (1) completed validated psychological questionnaires (visual analogue scale of stress, state trait anxiety inventory, perceived stress scale, fer...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
Abstract BACKGROUND: Pregnancies following assisted reproductive technology (ART) may have elevated potential risk of pregnancy loss (PL) when compared to natural conception. However, rare studies comprehensively analyzed the IVF/ICSI cycle-dependent factors for loss of clinical pregnancy. Therefore, we aimed to determine the ART subgroup-specific risks of PL throughout pregnancy and explore different risk factors for early miscarriage and late miscarriage among pregnancies conceived through ART. METHODS: A retrospective cohort study was launched in two infertility treatment centers in Nanjing and Changzhou i...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
AbstractAsherman ’s Syndrome (AS) is an acquired condition defined by the presence of intrauterine adhesions (IUA) that cause symptoms such as menstrual abnormalities, pelvic pain, infertility, recurrent miscarriage, abnormal placentation and attendant psychological distress. Classically, AS is considered an iatro genic disease triggered by trauma to the pregnant uterus. Different factors can cause the destruction of the endometrium, thus affecting the endometrial stem cell niche and creating IUAs. Curettage of the pregnant uterus appears to be the most common source of this destruction. Nevertheless, some AS cases h...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
Celiac disease (CD) is a disorder characterized by an autoimmune reaction triggered by sensitivity to gluten, the protein component of wheat, barley, and rye. Celiac disease is present in approximately 1% –2% of the general population, and existing studies have postulated a potential effect on duration of reproductive years, fertility, and pregnancy outcomes. There have been multiple meta-analyses of cohort studies and case–control studies that attempt to elucidate the association between reprodu ctive disorders and incidence of CD (1, 2); these studies found associations between unexplained infertility, recurr...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
​BY GREGORY TAYLOR, DO, &JACKLYN MCPARLANE​, DOA 31-year-old woman with a significant medical history for one ectopic pregnancy and five spontaneous abortions presented with abdominal pain and vaginal bleeding. Her symptoms started abruptly two days earlier, and the pain was located in the right lower quadrant, which had become diffuse and she described as sharp. She was also experiencing nausea, vomiting, and vaginal bleeding.She stated she had been spotting for five days and soaking up to four pads a day. Her last menstrual period was two months before, and a home pregnancy test was positive. Her presentation was...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
ConclusionFindings revealed an improvement in pregnancy rates following hCG administration in FET cycles.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
Publication date: Available online 6 January 2018Source: Middle East Fertility Society JournalAuthor(s): Kamal M. Zahran, Waleed A. Mostafa, Ahmed M. Abbas, Mansour A. Khalifa, Gamal H. SayedAbstractObjectiveTo compare the effect of adjunctive use of cabergoline with clomiphene citrate (CC) in infertile polycystic ovarian syndrome (PCOS) patients with normal prolactin level.Study designA randomized clinical trial (NCT 02644304).SettingAssiut University Hospital, Assiut, Egypt.Materials and methodsInfertile euprolactinemic PCOS patient were recruited and randomized in a 1:1 ratio to CC plus cabergoline or CC alone. All pati...
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
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