Acute leukaemia and myelodysplastic syndromes with chromosomal rearrangement involving 11q23 locus, but not MLL gene

Conclusions 11q23+/MLL– occurs rarely, involving different partner chromosomes and showing clinical and pathological features and disease subtypes different from those cases with MLL rearrangement. 11q23+/MLL– appears to be associated with clonal evolution/disease progression in acute leukaemia, a high risk for AML progression in MDS/CMML and a high incidence of disease relapse.

http://jcp.bmj.com/cgi/content/short/70/3/244?rss=1

Source: Journal of Clinical Pathology - February 15, 2017 Category: Pathology Authors: Zuo, W., Wang, S. A., DiNardo, C., Yabe, M., Li, S., Medeiros, L. J., Tang, G. Tags: Original article Source Type: research