Sequential allocation trial design in anesthesia: an introduction to methods, modeling, and clinical applications

In conclusion the up‐and‐down method can be more efficient than nonsequential designs for the estimation of the median dose/intervention level for a given intervention (ED50). The biased coin approach or continual reassessment method are preferred for the estimation of higher or lower tail quantiles such as ED90 or ED10. Continual reassessment method may be superior if knowledge of the dose–response relationship is available for the drug of interest.
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: Educational Review Source Type: research