Perspective Fibroblasts become fat to reduce scarring

Following cutaneous injury in adult mammals, one of two outcomes can occur: successful healing with scar formation or nonsuccessful healing and a chronic wound. In humans, scar formation can be classified in terms of “normal scar” formation versus pathologically increased fibrosis, as seen in hypertrophic scarring and keloids (1). Although scarring does not look or function like surrounding unwounded skin, it allows one to survive injury (and hence, procreate). However, extensive scarring from burns and conditions such as scleroderma or epidermolysis bulosa are not only unsightly but also contribute to substantial morbidity owing to loss of functionality in affected tissues and limbs. In the United States alone, there are greater than 50 million incisions and lacerations each year, all of which heal with some degree of scarring (2). Thus, scarring represents an enormous and growing medical burden in our aging population. On page 748 of this issue, Plikus et al. (3) demonstrate that scarring could be mitigated by controlling fibroblast plasticity. This has very exciting translational implications for treating scar formation during wound repair. Authors: Charles K. F. Chan, Michael T. Longaker
Source: ScienceNOW - Category: Science Authors: Tags: Tissue Regeneration Source Type: news

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Publication date: Available online 3 April 2020Source: The Annals of Thoracic SurgeryAuthor(s): Mehmet Alagoz, Halil Sencer Akdeniz, Ahmet Dolapoglu
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 3 April 2020Source: The Annals of Thoracic SurgeryAuthor(s): Daniel L. Miller
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Abstract Repair of injured tissues requires angiogenesis, the growth of new blood vessels from pre-existing ones. Cutaneous wound healing is a complex and dynamic process by which skin tissue repairs itself after injury; however, how endothelial cells and pericytes form new blood vessels during cutaneous wound angiogenesis remains unclear. We recently developed a fluorescence-based live imaging system to analyze cutaneous wound angiogenesis in adult zebrafish. Employing this system, we found that endothelial cells and pericytes remain in a quiescent state in normal skin tissue, whereas cutaneous injury immediately...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
CONCLUSIONS: Despite more comorbidities in the over 65s, this study shows that there is no significant difference in complication rates between laparoscopic and open inguinal hernia repair irrespective of age category. Selection bias for the type of repair and the potential for an alpha error mean larger studies are required to show equivalence. PMID: 32243111 [PubMed - as supplied by publisher]
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
CONCLUSION: Delayed repair, up to 2 months later, for uncomplicated infant hernia carries a small risk of incarceration but does not increase the rate of strangulation or other complications. PMID: 32243110 [PubMed - as supplied by publisher]
Source: South African Journal of Surgery - Category: Surgery Tags: S Afr J Surg Source Type: research
CONCLUSION: Gallbladder perforations are common during laparoscopic cholecystectomy due to traction with forceps or inflammation. Careful inspection for spillage stone should be done. KEY WORDS: Laparoscopic cholecystectomy, Retained Stones, hernia, Trocar Site. PMID: 32242545 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Conclusion. The ankle ligament reconstruction with additional polyester tape augmentation is an effective technique in treating chronic ankle instability with a satisfactory surgical outcome. PMID: 32242523 [PubMed - in process]
Source: Ortopedia Traumatologia Rehabilitacja - Category: Orthopaedics Tags: Ortop Traumatol Rehabil Source Type: research
This study aimed to establish categories and evaluate sites of hand burn s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
The discrimination between earthquakes and explosions is a serious issue in seismic signal analysis. This paper proposes a seismic discrimination method using support vector machine (SVM), wherein the amplitudes of the P-wave and the S-wave of the seismic ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
Publication date: Available online 3 April 2020Source: Arthroscopy TechniquesAuthor(s): Graeme P. Hopper, Joanne M. Jenkins, Gordon M. Mackay
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
More News: Burns | Epidermolysis Bullosa | Gastroschisis Repair | Keloids | Scleroderma | Skin