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Postmenopausal hormone therapy exceeding ten years may protect from dementia

Postmenopausal estrogen-based hormone therapy lasting longer than ten years was associated with a decreased risk of Alzheimer's disease in a large study. The study explored the association between postmenopausal hormone replacement therapy, Alzheimer's disease, dementia and cognition in two nation-wide case-control studies and two longitudinal cohort studies. The largest study comprised approximately 230,000 Finnish women and the follow-up time in different studies was up to 20 years.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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The exam, called the Moca, is widely used in doctor ’ s offices, but it is not sophisticated enough to diagnose mental decline, experts say.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Tests (Medical) Memory Elderly Dementia Trump, Donald J Source Type: news
There are signs from past years to suggest that Alzheimer's disease is a reversible condition, at least in its earlier stages. In other words, that there is little loss of the structures holding the data of the mind, and the condition degrades the operation of the mind, not its underpinnings. The consensus, however, is that this stops being the case further into the progression of the disease, and significant losses do in fact occur. The researchers here disagree with that consensus, providing data to suggest that even in later stages the condition is not destroying significant numbers of synapses. This will definitely req...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
This article introduces Stanford Health Care's Memory Support Program (MSP) as a model for culturally competent dementia care that spans inpatient and outpatient settings. The case study of an African American patient and family dealing with an Alzheimer's disease diagnosis and comorbid conditions is presented and explored to illustrate the MSP model. The authors make recommendations for the implementation of similar continuum of care services in other institutions. As research continues to show, the cultural competence of medical professionals can impact patient quality of care and health outcomes. More research is needed...
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
AbstractDelivering peptide-based drugs to the brain is a major challenge because of the existence of the blood-brain barrier (BBB). To overcome this problem, cell-penetrating peptides derived from proteins that are able to cross biological membranes have been used as cell-permeable and brain-penetrant compounds. An example is the transactivator of transcription protein transduction domain (Tat) of the human immunodeficiency virus. The basic domain of Tat is formed of arginine and lysine amino acid residues. Tat has been used as brain-penetrant carrier also in therapies for Alzheimer disease (AD), the most common form of de...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Discussion The rs10984186 risk and rs4837766 protective polymorphic variants of the CDK5RAP2 gene might act as potent genetic modifiers for AD risk and/or conversion by modulating the expression of this gene.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Conditions:   Dementia;   Dementia Alzheimers;   Dementia, Vascular;   Dementia, Mixed Intervention:   Other: No interventions Sponsors:   University of Michigan;   National Institutes of Health (NIH) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Dementia Intervention:   Sponsors:   McGill University;   Canadian Institutes of Health Research (CIHR);   Alzheimer Society of Canada;   Sanofi;   New Brunswick Health Research Foundation;   Saskatchewan Health Research Foundation;   Women's Brain Health Initiative;   Michael Smith Foundation for Heal th Research;   Alzheimer's Research UK;   Alberta Prion Research Institute;   Nova Scotia Hea...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Dementia;   Dementia Alzheimers;   Dementia, Vascular;   Dementia, Mixed Intervention:   Other: No interventions Sponsors:   University of Michigan;   National Institutes of Health (NIH) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Dementia Intervention:   Sponsors:   McGill University;   Canadian Institutes of Health Research (CIHR);   Alzheimer Society of Canada;   Sanofi;   New Brunswick Health Research Foundation;   Saskatchewan Health Research Foundation;   Women's Brain Health Initiative;   Michael Smith Foundation for Heal th Research;   Alzheimer's Research UK;   Alberta Prion Research Institute;   Nova Scotia Hea...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Dementia;   Dementia Alzheimers;   Dementia, Vascular;   Dementia, Mixed Intervention:   Other: No interventions Sponsors:   University of Michigan;   National Institutes of Health (NIH) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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