Local disease control in ocular adnexal lymphoproliferative disorders: comparative outcomes of MALT versus non-MALT histologies

We present a single-center, large cohort, retrospective study of the efficacy of involved field radiation therapy (IFRT) in ocular adnexal lymphoproliferative disorders (OALDs). Failure free survival (FFS), complete remission (CR), and local, regional and distant failure were determined for 112 patients with marginal zone lymphoma of mucosa associated lymphoid tissue (MALT) OALDs (n=71) and non-MALT OALDs (n=41) cohorts. Fifty-six patients with MALT OALD and 26 patients with non-MALT OALD received IFRT only (without any planned concurrent or sequential systemic chemo- or chemo-immunotherapies). Among these OALD cohorts treated with only IFRT, CR was achieved in 49 (87.5%) patients in the MALT cohort and 23 (88.4%) in the non-MALT cohort (p=0.99). Clinically, resolution of symptoms occurred in 83.3% and 93.3% of MALT and non-MALT cohorts respectively. Local failure occurred in 4 (7.1%) patients in the MALT cohort, compared to 4 (15.3%) patients in the non-MALT cohort (p= 0.24). Regional failure (or extra-orbital failure) occurred in 5 (8.9%) patients in the MALT cohort and in 3 (11.5%) of non-MALT patients in the non-MALT cohort (p= 0.71). Distant failure was reported in 1 (1.7%) and 2 patients (7.6%) in MALT and non-MALT cohorts respectively (p= 0.18). The median follow-up of survivors was 5.1 (0.1-22.5) in MALT and 3.9 (0.1-22.9) years in the non-MALT cohort. The 5 year and 10-year failure-free survival was 95% (95% CI 88-100) and 83% (95% CI 70-98) for ocular MALT and 67% (...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research