One-Year Swallowing Outcomes in Patients Treated with Prophylactic Gabapentin During Radiation-Based Treatment for Oropharyngeal Cancer

AbstractRecent investigations by our study team have demonstrated patients using gabapentin for pain management during chemoradiotherapy (CRT) do well maintaining swallowing during treatment with less need for narcotic pain medication, PEG dependence, weight loss, and short-term swallowing morbidity. The purpose of this investigation was to characterize the long-term swallowing function of these patients 1-year following treatment. Sequential patients receiving CRT for oropharyngeal cancer and concurrent gabapentin were evaluated 1-year following treatment for swallowing outcomes. Functional Oral Intake Scores (FOIS) were utilized to assess diet level. The MD Anderson Dysphagia Inventory (MDADI) was chosen to evaluate patient perception of swallowing function. Videofluoroscopic swallowing studies were completed approximately 1 year after treatment to assess physiologic outcomes as well as Penetration Aspiration Scores (PAS). Data from 26 consecutive participants were available for analysis. The majority of patients had advanced stage disease (Stage 3 –4). No patients had a PEG tube 1-year following treatment, and the mean FOIS score was 6.83. Pharyngeal deficits were infrequent with reduced pharyngeal constriction and prominence/early closure of cricopharyngeus predominating. Mean PAS score was 1.5, indicating that the majority of patients had either no laryngeal penetration/aspiration, or transient penetration that was fully cleared. Mean MDADI score was 85.52, indicat...
Source: Dysphagia - Category: Speech Therapy Source Type: research

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Authors: Dandachi D, Wilson Dib R, Fernández-Cruz A, Jiang Y, Chaftari AM, Hachem R, Raad I Abstract BACKGROUND: The characteristics and management of invasive pulmonary aspergillosis (IPA) in patients with hematologic malignancies are well known, but IPA in patients with solid tumors is not well described. METHODS: We retrospectively reviewed all Aspergillus-positive cultures at a tertiary cancer center during 2004-2017. We identified 101 patients with IPA and solid tumors. We analyzed the association between clinical features and treatment and 12-week mortality and response to antifungal therapy. R...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
Publication date: 19 September 2018Source: Neuron, Volume 99, Issue 6Author(s): Lindsey M. Snyder, Michael C. Chiang, Emanuel Loeza-Alcocer, Yu Omori, Junichi Hachisuka, Tayler D. Sheahan, Jenna R. Gale, Peter C. Adelman, Elizabeth I. Sypek, Stephanie A. Fulton, Robert L. Friedman, Margaret C. Wright, Melissa Giraldo Duque, Yeon Sun Lee, Zeyu Hu, Huizhen Huang, Xiaoyun Cai, Kimberly A. Meerschaert, Vidhya Nagarajan, Toshiro HiraiSummaryPrimary afferents are known to be inhibited by kappa opioid receptor (KOR) signaling. However, the specific types of somatosensory neurons that express KOR remain unclear. Here, using a newl...
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: 19 September 2018Source: Neuron, Volume 99, Issue 6Author(s): Paul V. Naser, Rohini KunerWith the current unmet demand for effective analgesics and the opioid crisis, pain relief without major central adverse effects is highly appealing. In this issue of Neuron, Snyder et al. (2018) report on the localization, functions, and therapeutic potential of kappa opioid receptors in peripheral sensory neurons.
Source: Neuron - Category: Neuroscience Source Type: research
More than half of all UN countries will fail to honor their commitment to reduce premature deaths from cancer, cardiovascular disease, chronic respiratory disease and diabetes by 2030, a new analysis predicts.
Source: - Health - Category: Consumer Health News Source Type: news
Jakob von Frieling, Christine Fink, Jacob Hamm, Kenneth Klischies, Michael Forster, Thomas C. G. Bosch, Thomas Roeder, Philip Rosenstiel, Felix Sommer
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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Source: Results in Physics - Category: Physics Source Type: research
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Publication date: Available online 19 September 2018Source: Biosensors and BioelectronicsAuthor(s): Danni Wang, Rui Guo, Yunyun Wei, Yingzhi Zhang, Xiayu Zhao, Zhangrun XuAbstractDetection of telomerase activity is crucial for the telomerase-related early diagnosis of cancer and drug screening. Herein, a multicolor visual telomerase detection method with high sensitivity was developed based on the etching of hexadecyl trimethyl ammonium bromide -stablized Au nanorods (Au NRs) by the oxidation state 3,3′,5,5′-tetramethylbenzidine sulfate (TMB2+). In order to meet the demand of bare-eye inspection, an enzyme-free...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
A for-profit venture with exclusive rights to use the center ’ s vast archive of tissue slides has generated concerns at the nonprofit cancer center.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Artificial Intelligence Tissue (Human) Conflicts of Interest Hospitals Baselga, Jose Venture Capital Federal Taxes (US) Nonprofit Organizations Memorial Sloan-Kettering Cancer Center Paige.AI David Klimstra Thomas Fuchs Norman Selb Source Type: news
Clelia Madeddu, Giulia Gramignano, Giorgio Astara, Roberto Demontis, Elisabetta Sanna, Vinicio Atzeni, Antonio Macci ò
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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