Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis

Substance P (SP) is produced at high levels in the central nervous system (CNS), and its target receptor, neurokinin 1 receptor (NK-1R), is expressed by glia and leukocytes. This tachykinin functions to exacer...

Source: Journal of Neuroinflammation - February 15, 2017 Category: Neurology Authors: Alejandra N. Martinez, Amanda R. Burmeister, Geeta Ramesh, Lara Doyle-Meyers, Ian Marriott and Mario T. Philipp Source Type: research