Self-regulating ubiquitin ligases

Occasional auto-modification of ubiquitin ligases typically leads to their proteasomal destruction, but new findings published in The EMBO Journal now show that in the case of Rsp5/Nedd4, auto-ubiquitylation instead triggers oligomerization and concomitant reduction of ligase activity. This novel mechanism therefore creates silenced ligases that remain poised for reactivation.

Source: EMBO Journal - February 14, 2017 Category: Molecular Biology Authors: Hill, S., Kleiger, G. Tags: Post-translational Modifications, Proteolysis & Proteomics News [amp ] Views Source Type: research