Scripps Florida collaboration awarded $3.3 million to develop next-generation breast cancer therapies
(Scripps Research Institute) A pair of scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to $3.3 million from the National Cancer Institute of the National Institutes of Health (NIH) to create the next generation of breast cancer treatments for the thousands of patients whose current treatment options are limited.
Conclusion: Propolis extracts may be important economically, allowing a relatively inexpensive cancer treatment associated to lower concentrations of drugs. In this review, the activity and mechanisms of action of propolis and CAPE on breast cancer cells are discussed.
ConclusionApplication of cytostatic drugs in combination with adaptogenic plant extracts induced significant changes in transcriptome-wide microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects of adaptogens on FEC induced adverse events in cancer chemotherapy.Graphical abstract
In this study we further explore the inhibitory effects of this molecule in cancer cells. We found that Pimozide inhibited cell proliferation in a dose- and time-dependent manner in MDA-MB-231 breast cancer cells and A549 lung cancer cells. Furthermore, we found that Pimozide also promoted apoptosis as demonstrated by cell cycle arrest and induction of double-strand DNA breaks but did not result in any effect in the non-transformed MCF10A breast cell line. In order to shed new lights into the molecular pathways affected by Pimozide, we show that Pimozide downregulated RAN GTPase and AKT at both protein and mRNA levels and ...
New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8NJ03350A, PaperDipranjan Laha, Kunal Pal, Angshuman Ray Chowdhuri, Pravat Kumar Parida, Sumanta Kumar Sahu, Kuladip Jana, Parimal Karmakar Curcumin has shown therapeutic activity against triple negative breast cancer cell (TNBC), but it shows low efficacy and low bioavailability when administered as a free drug. We have developed a... The content of this RSS Feed (c) The Royal Society of Chemistry
ConclusionsAlthough all patients with breast cancer stand to benefit from advances in breast cancer therapy, the current results demonstrate that women who have participated in mammography screening obtain a significantly greater benefit from the therapy available at the time of diagnosis than do those who have not participated.
ang Breast cancer (BC) is one of the most prominent diseases in the world, and the treatments for BC have many limitations, such as resistance and a lack of reliable biomarkers. Currently the Hippo pathway is emerging as a tumor suppressor pathway with its four core components that regulate downstream transcriptional targets. In this review, we introduce the present targeted therapies of BC, and then discuss the roles of the Hippo pathway in BC. Finally, we summarize the evidence of the small molecule inhibitors that target the Hippo pathway, and then discuss the possibilities and future direction of the Hippo-targeted...
(American Association for Cancer Research) An evaluation of breast cancer patients enrolled in Medicaid showed that states that expanded Medicaid during 2011 to 2017 had a 27 percent increase in prescriptions for hormonal therapy medications compared to states that did not expand Medicaid during the same period.
Publication date: 1 February 2019Source: Materials Science and Engineering: C, Volume 95Author(s): Kunal Pal, Shubham Roy, Pravat Kumar Parida, Ananya Dutta, Souravi Bardhan, Sukhen Das, Kuladip Jana, Parimal KarmakarAbstractAmong the different types of biomaterials, natural excipients gum acacia (GA) is economic and has the potential for controlled drug delivery. We have synthesized GA microspheres by co-precipitation method and characterized them by XRD, FESEM, 1H NMR, FTIR, UV visible spectra and DLS. Despite its potential anti-cancer activity, solubility of curcumin is very low rendering its limit in application. We ha...
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b12590
This study puts mitochondria in a spotlight for cancer therapy and places antibiotics as effective agents for eliminating CSC and resistant cells. PMID: 30373788 [PubMed - as supplied by publisher]