Toxoplasma gondii exposure and Parkinson's disease: a case-control study

Conclusions The results do not support an association between T. gondii infection and Parkinson's disease. However, T. gondii infection might have an influence on certain symptoms of Parkinson's disease. Further research to elucidate the role of T. gondii exposure on Parkinson's disease is warranted.
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access, Epidemiology, Infectious diseases, Neurology, Public health Research Source Type: research

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Transcranial non-invasive brain stimulation (NIBS) techniques include particularly repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), although other non-invasive stimulation techniques have also been employed. The rTMS uses a rapidly changing magnetic field to induce currents and action potentials in underlying brain tissue. The tDCS involves the application of weak (1 –2mA) electrical currents to modulate neuronal membrane potential. Although the precise mechanisms of NIBS aftereffects have not been fully elucidated, rTMS has been shown to modulate several neurotr...
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Abstract Our previous studies have indicated that depression and declined cognition have been involved in some neurodegenerative diseases including Stroke, Parkinson's diseases and Vascular Parkinsonism. Post-stroke depression (PSD) is the most common psychiatric disorder following a stroke and has high morbidity and mortality. Studies on PSD are increasingly common, but the specific mechanisms remain unknown. Current research mainly includes clinical and animal aspects. Questionnaires and peripheral blood examination are two of the most common methods used to study clinical PSD. The results of questionnaires are ...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
In this study, unilateral 6-hydroxydopamine lesions of the substantia nigra pars compacta (SNc) in rats induced depressive-like behaviors and led to hyperactivity of LHb neurons compared to SNc sham-lesioned rats. Interestingly, intra-LHb injection of AMPAR agonist (S)-AMPA produced antidepressant-like effects in the two groups of rats and antagonist NBQX induced depressive-like behaviors, although (S)-AMPA excited LHb neurons and NBQX inhibited these neurons. We further found that intra-LHb injection of (S)-AMPA excited dopaminergic neurons in the anterior ventral tegmental area (aVTA) and serotonergic neurons in the dors...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
AbstractPTEN-induced kinase 1 (PINK1) mutations can cause early-onset Parkinson ’s disease and patients are likely to develop cognitive decline, depression, and dementia. Several neurophysiological studies have demonstrated PINK1 deficiency impairs striatal and hippocampal presynaptic plasticity. Dendritic spine postsynaptic abnormalities are common in neurological diseases; however, whether PINK1 silencing modifies dendritic spine dynamics of hippocampal neurons is unclear. To address this question, confocal images of mouse cultured hippocampal neurons transfected with plasmids to silence PINK1 were analyzed. These ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
ConclusionsThe symptom of subjective fatigue could predict the progression of PD.
Source: Neurological Sciences - Category: Neurology Source Type: research
CONCLUSIONS: Findings suggest a possible relationship between PD and FP. Clinicians should keep in mind the possibility of functional symptoms in PD patients. PMID: 31466517 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
Authors: Amieva H, Meillon C, Proust-Lima C, Dartigues JF Abstract BACKGROUND: Dementia, stroke, depression, and disability are frequent in late life and are major causes of quality of life disruption and family burden. Even though each of these disorders relies on specific pathogenic processes, a common clinical manifestation is psychomotor slowing. OBJECTIVE: We assessed the relevance of a simple marker of low psychomotor speed in predicting several brain outcomes: dementia, Alzheimer's disease (AD), Parkinson's disease (PD), stroke, depressive symptoms, and disability in activities of daily living (ADL) and ...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSION: DBS of subthalamic nucleus should be seen as the most hazardous place of implantation. As a result there is a strong need of "gold standards" based on the connectivity research and closer cooperation of scientists and clinicians. PMID: 31452489 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Preoperative and postoperative mental health status (MHS) of total joint arthroplasty patients can affect immediate and long-term outcomes following surgery. Alterations in MHS can be acute or chronic. The most common etiologies include acute changes due to (1) delirium or stroke, (2) movement disorders (Alzheimer dementia, Parkinson disease, multiple sclerosis, epilepsy), and (3) mood/behavior disorders (major depressive disorder, anxiety, bipolar disorder, schizophrenia). Across etiologies, alterations in MHS are associated with worse clinical/patient-reported outcomes and greater total cost of care. Prevention via pharm...
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Symposium Source Type: research
Authors: Lee W, Williams DR, Evans A Abstract Background: While numerous validated questionnaires measuring psychiatric symptoms in Parkinson's disease (PD) are available, a quick multifaceted screening tool is lacking. Objective: To generate the Brief Psychiatric Questionnaire (BPQ) that quickly screens for depression, anxiety, and apathy and to evaluate its content validity against three reference scales. Methods: Forty-seven questions were drafted and measured against the Geriatric Depression Scale (GDS), State Trait Anxiety Inventory (Form Y2) (STAI-Y2), and Apathy Evaluation Scale (AES). Data were redu...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
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