Caulerpenyne from Caulerpa taxifolia: A comparative study between CPC and classical chromatographic techniques

Publication date: Available online 13 February 2017 Source:Phytochemistry Letters Author(s): Estelle Sfecci, Céline Le Quemener, Thierry Lacour, Lionel Massi, Philippe Amade, Grégoire Audo, Mohamed Mehiri Caulerpenyne (Cyn) is a cytotoxic compound firstly isolated in 1978 from Caulerpa prolifera. This metabolite, constituted by a highly reactive diacetoxybutadiene moiety, exhibited a wide range of biological properties with mainly antibacterial properties and antitumoral activities. Few structure–activity relationships (SAR) are available to design more potent bioactive derivatives by pharmacomodulation. Cyn can be produced by total synthesis or extracted from natural sources in particular the green alga Caulerpa taxifolia. Since conventional chromatographic procedures to isolate Cyn from C. taxifolia are time- and solvent-consuming, it was crucial to find a more efficient process to obtain pure Cyn. In our study, Cyn has been purified from C. taxifolia with two different techniques: Centrifugal partition chromatography (CPC) and a classical chromatographic process. The comparative study showed that CPC constitutes a very simple and efficient process to access Cyn. Graphical abstract

Source: Phytochemistry Letters - February 12, 2017 Category: Chemistry Source Type: research