A Plasmodium vivax plasmid DNA- and adenovirus-vectored malaria vaccine encoding blood stage antigens AMA1 and MSP142 in a prime/boost heterologous immunization regimen partially protects Aotus monkeys against blood stage challenge.

In conclusion, P. vivax plasmid DNA/Ad5 vaccine encoding blood stage parasite antigens AMA1 and MSP142 in a heterologous prime/boost immunization regimen, provided significant protection against blood-stage challenge in Aotus monkeys, indicating the suitability of these antigens and regimen for further development. PMID: 28179404 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28179404?dopt=Abstract

Source: Clinical and Vaccine Immunology - February 7, 2017 Category: Allergy & Immunology Authors: Obaldia N, Stockelman MG, Otero W, Cockrill JA, Ganeshan H, Abot EN, Zhang J, Limbach K, Charoenvit Y, Doolan DL, Tang DC, Richie TL Tags: Clin Vaccine Immunol Source Type: research